TRH, thyrotropin releasing hormone, 7200

N. diseases: 230; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human PRI-2191 alone had no effect on gene expression, but it enhanced the seizure-evoked expression of HSP-70, had an opposite effect on BDNF mRNA level and did not affect prepro-TRH mRNA level. 15781040 2005
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype BEFREE Thyrotropin-releasing hormone (TRH) therapy reduced his seizures and improved the findings of EEG without cardiac side effects. 14636357 2003
CUI: C0036572
Disease: Seizures
Seizures
0.310 Biomarker phenotype CTD_human These data showed that pilocarpine- and kainate-induced seizures enhanced likewise preproTRH mRNA in the dentate gyrus; on the other hand, they differed with respect to time- and structure-related changes in TRH tissue levels and TRH receptors. 10443546 1999