|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
BEFREE |
Two hypertension cohorts were examined-new antihypertensive drug users (incident hypertension) and patients requiring titration to a fourth antihypertensive (incident treatment-resistant hypertension [TRH]).
|
30052747 |
2018 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
BEFREE |
Following injection in rodents, TRH has multiple effects including increased blood pressure and breathing.
|
29674333 |
2018 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
RGD |
Thus the TRH-leptin interaction may contribute to the strong association between hypertension and obesity.
|
17227965 |
2007 |
|
Hypertensive disease
|
0.550 |
GeneticVariation
|
group |
BEFREE |
Five polymorphisms in five genes, CAST(calpastatin), LIPC (hepatic lipase), SLC4A1 (band 3 anion transporter), TRH (thyrotropin-releasing hormone), and VWF (von Willebrand factor), were significantly associated with both blood pressure variation and hypertension.
|
17137217 |
2006 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
BEFREE |
As it has been demonstrated that hypertensive patients have a blunted TSH response to TRH injection, suggesting a defect in the TRHR, we postulate that the TRHR gene is involved in human hypertension.
|
11566956 |
2001 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
BEFREE |
To summarize, central TRH overproduction in periventricular areas induced by I.C.V. transfection produces hypertension in rats which is reversed by specific antisense treatment.
|
9323019 |
1997 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
CTD_human |
In addition, intraventricular administration of TRH, LHRH or LH caused tachycardia, hypertension and a reduction in the epinephrine-induced reflex bradycardia.
|
6350720 |
1983 |
|
THYROTROPIN-RELEASING HORMONE DEFICIENCY
|
0.500 |
GeneticVariation
|
disease |
ORPHANET |
Isolated idiopathic central hypothyroidism in an adult, possibly caused by thyrotropin releasing hormone (TRH) deficiency.
|
20687402 |
2010 |
|
THYROTROPIN-RELEASING HORMONE DEFICIENCY
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Hypothalamic hypothyroidism
|
0.410 |
GeneticVariation
|
disease |
ORPHANET |
Isolated idiopathic central hypothyroidism in an adult, possibly caused by thyrotropin releasing hormone (TRH) deficiency.
|
20687402 |
2010 |
|
Hypothalamic hypothyroidism
|
0.410 |
Biomarker
|
disease |
BEFREE |
TRH knockout mice show characteristic phenotypes of tertiary hypothyroidism, but no morphological changes in their cerebellum.
|
18418668 |
2008 |
|
Hypothalamic hypothyroidism
|
0.410 |
Biomarker
|
disease |
HPO |
|
|
|
|
Alcoholic Intoxication, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
The thyrotropin releasing hormone stimulation test in alcoholism.
|
8554651 |
1995 |
|
Alcoholic Intoxication, Chronic
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Thyrotropin and prolactin responses to thyrotropin-releasing hormone in young men at high or low risk for alcoholism.
|
8561281 |
1995 |
|
Alcoholic Intoxication, Chronic
|
0.350 |
Biomarker
|
disease |
PSYGENET |
The thyrotropin releasing hormone stimulation test in alcoholism.
|
8554651 |
1995 |
|
Alcoholic Intoxication, Chronic
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Thyrotropin and prolactin responses to thyrotropin-releasing hormone in young men at high or low risk for alcoholism.
|
8561281 |
1995 |
|
Alcoholic Intoxication, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
TSH response to TRH and family history of alcoholism.
|
2110006 |
1990 |
|
Alcoholic Intoxication, Chronic
|
0.350 |
Biomarker
|
disease |
PSYGENET |
The results of the TRH test and the DST point to similar endocrinological patterns in alcoholics as in depressive patients and thus support the hypothesis of a link between alcoholism and depression.
|
2543997 |
1989 |
|
Alcoholic Intoxication, Chronic
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
The results of the TRH test and the DST point to similar endocrinological patterns in alcoholics as in depressive patients and thus support the hypothesis of a link between alcoholism and depression.
|
2543997 |
1989 |
|
Alcoholic Intoxication, Chronic
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Various types of phenotypic markers are discussed and alcoholism is taken as a model for a more detailed discussion of available putative phenotypic markers and of research strategies to be used, namely the pharmacological challenge in high risk subjects (e.g. ethanol and TRH challenge).
|
6439854 |
1984 |
|
Alcoholic Intoxication, Chronic
|
0.350 |
Biomarker
|
disease |
BEFREE |
Various types of phenotypic markers are discussed and alcoholism is taken as a model for a more detailed discussion of available putative phenotypic markers and of research strategies to be used, namely the pharmacological challenge in high risk subjects (e.g. ethanol and TRH challenge).
|
6439854 |
1984 |
|
Mental Depression
|
0.340 |
Biomarker
|
disease |
PSYGENET |
These results suggest that in male mice GHRH deficiency brings about an increased physical activity and decreased anxiety- and depression-related behaviour, possibly related to increased TRH and decreased NE levels in the brain.
|
25028079 |
2014 |
|
Mental Depression
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Female, but not male, TRH-R2 knockout mice exhibit moderately increased depression-like and reduced anxiety-like phenotypes.
|
19078951 |
2009 |
|
Mental Depression
|
0.340 |
Biomarker
|
disease |
PSYGENET |
TRH and TRH analogs are promising clinical therapeutic agents for inducing arousal effects, amelioration of mental depression, and improvement of cerebellar ataxia.
|
18418668 |
2008 |
|
Mental Depression
|
0.340 |
Biomarker
|
disease |
BEFREE |
TRH and TRH analogs are promising clinical therapeutic agents for inducing arousal effects, amelioration of mental depression, and improvement of cerebellar ataxia.
|
18418668 |
2008 |