Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0087012
Disease: Ataxia, Spinocerebellar
Ataxia, Spinocerebellar 		0.300 Biomarker disease CTD_human
CUI: C0752120
Disease: Spinocerebellar Ataxia Type 1
Spinocerebellar Ataxia Type 1 		0.300 Biomarker disease CTD_human
CUI: C0752121
Disease: Spinocerebellar Ataxia Type 2
Spinocerebellar Ataxia Type 2 		0.300 Biomarker disease CTD_human
CUI: C0752122
Disease: Spinocerebellar Ataxia Type 4
Spinocerebellar Ataxia Type 4 		0.300 Biomarker disease CTD_human
CUI: C0752123
Disease: Spinocerebellar Ataxia Type 5
Spinocerebellar Ataxia Type 5 		0.300 Biomarker disease CTD_human
CUI: C0752124
Disease: Spinocerebellar Ataxia Type 6 (disorder)
Spinocerebellar Ataxia Type 6 (disorder) 		0.300 Biomarker disease CTD_human
CUI: C0752125
Disease: Spinocerebellar Ataxia Type 7
Spinocerebellar Ataxia Type 7 		0.300 Biomarker disease CTD_human
CUI: C0004134
Disease: Ataxia
Ataxia 		0.110 Biomarker phenotype HPO
CUI: C0231686
Disease: Gait, Unsteady
Gait, Unsteady 		0.100 Biomarker phenotype HPO
CUI: C0740279
Disease: Cerebellar atrophy
Cerebellar atrophy 		0.100 Biomarker disease HPO
CUI: C0742028
Disease: Cerebellar vermis atrophy
Cerebellar vermis atrophy 		0.100 Biomarker phenotype HPO
CUI: C0751837
Disease: Gait Ataxia
Gait Ataxia 		0.100 Biomarker phenotype HPO
CUI: C1843921
Disease: Postural instability
Postural instability 		0.100 Biomarker phenotype HPO
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.020 Biomarker disease BEFREE <i>Results</i>: We identified three '<i>prostate-associated</i>' genes whose expression is upregulated in prostate TECs: TRPV2 as a positive modulator of TEC proliferation, TRPC3 as an endothelial PCa cell attraction factor and TRPA1 as a critical TEC angiogenic factor in vitro and in vivo. 31288452 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.020 Biomarker disease BEFREE <i>Results</i>: We identified three '<i>prostate-associated</i>' genes whose expression is upregulated in prostate TECs: TRPV2 as a positive modulator of TEC proliferation, TRPC3 as an endothelial PCa cell attraction factor and TRPA1 as a critical TEC angiogenic factor in vitro and in vivo. 31288452 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.340 AlteredExpression group BEFREE TRPC3 expression is associated with hypertension and hypoxic conditions in human cerebral vascular tissue. 21957871 2011
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.030 AlteredExpression disease BEFREE TRPC3 expression was upregulated in atria from AF patients, goats with electrically maintained AF, and dogs with tachypacing-induced heart failure. 22992321 2012
CUI: C0018801
Disease: Heart failure
Heart failure 		0.050 AlteredExpression disease BEFREE TRPC3 expression was upregulated in atria from AF patients, goats with electrically maintained AF, and dogs with tachypacing-induced heart failure. 22992321 2012
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.050 AlteredExpression disease BEFREE TRPC3 expression was upregulated in atria from AF patients, goats with electrically maintained AF, and dogs with tachypacing-induced heart failure. 22992321 2012
CUI: C0162810
Disease: Cicatrix, Hypertrophic
Cicatrix, Hypertrophic 		0.010 AlteredExpression disease BEFREE TRPC3 is highly expressed in human hypertrophic scar tissue and mechanical stimuli are known to upregulate TRPC3 expression in human skin fibroblasts in vitro. 26108359 2015
CUI: C0018801
Disease: Heart failure
Heart failure 		0.050 AlteredExpression disease BEFREE TRPC3 and TRPC6, two members in the TRPC family, are highly expressed in the heart, and participate in the pathogenesis of cardiac hypertrophy and heart failure as a pathological response to chronic mechanical stress. 28645743 2017
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.050 AlteredExpression disease BEFREE TRPC3 and TRPC6, two members in the TRPC family, are highly expressed in the heart, and participate in the pathogenesis of cardiac hypertrophy and heart failure as a pathological response to chronic mechanical stress. 28645743 2017
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.020 Biomarker disease BEFREE TRPC3- and ET<sub>B</sub> receptor-mediated PI3K/AKT activation induces vasogenic edema formation following status epilepticus. 28764936 2017
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.010 AlteredExpression phenotype BEFREE Trpc3 mRNA expression was significantly elevated in kidneys of Trpc6<sup>-/-</sup> mice underwent UUO while the levels did not change in kidneys of neither WT nor in NZO mice underwent UUO. 31099508 2019
CUI: C0162429
Disease: Malnutrition
Malnutrition 		0.010 Biomarker disease BEFREE TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy. 31278358 2019