Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study showed the population structure of M. tuberculosis in several regions from Colombia with a dominance of the LAM and Haarlem sublineages, particularly in two major urban settings (Medellín and Cali).
|
24747767 |
2014 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As part of a major project to investigate protective and diagnostic immune markers against tuberculosis (TB), we measured antibody isotype responses to Mycobacterium tuberculosis (Mtb) antigens (LAM, Rv2031, and HBHA) in cohorts of 149 pulmonary tuberculosis patients (PTBP), 148 household contacts (HHCs), and 68 community controls (CCs) in an endemic setting.
|
29373577 |
2018 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, the M. tuberculosis population structure in this sample was dominated by LAM (64.8%) and T (33.0%) strains.
|
28230095 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genotypic characteristics of the M. tuberculosis predominant LAM strain that was responsible for 31 % of TB cases in this setting are presented.
|
17005791 |
2006 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Indeed, 84.9 % of all tuberculosis (TB) cases were attributed to the Haarlem, LAM or T families.
|
18566145 |
2008 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnostic accuracy of the LF-LAM test was assessed against a microbiological reference standard (definite tuberculosis) or a composite reference standard (definite and probable tuberculosis).
|
31024973 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that a large proportion of new TB infections in Vitoria is caused by prevalent Mtb genotypes belonging to the LAM family and RD<sup>Rio</sup> genotypes.
|
29422032 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Urine LAM testing can effectively identify tuberculosis in HIV-infected patients who are at a higher risk of mortality yet are unable to generate a sputum sample for diagnostic testing.
|
29282005 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Incremental diagnostic yield of adding LAM was the difference in the proportion of confirmed TB patients (positive Xpert or MTB culture) diagnosed by the algorithm with LAM compared to the algorithm without LAM.
|
28125693 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The finding of multiple families of M. tuberculosis strains (S, T, LAM, Haarlem), their presumed links with the major genetic groups (MGG) of M. tuberculosis complex, supports the view of independent introduction of several ancestral genotypes in Sicily and in Sardinia.
|
15639747 |
2005 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Delayed diagnosis and treatment of tuberculosis in HIV+ patients in Mozambique: A cost-effectiveness analysis of screening protocols based on four symptom screening, smear microscopy, urine LAM test and Xpert MTB/RIF.
|
30024890 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stratified by CD4 cell count, pooled sensitivity increased, and specificity decreased with lower CD4 cell count.Unselected participants not assessed for signs and symptoms of tuberculosisLF-LAM pooled sensitivity was 35% (22% to 50%), (moderate-certainty evidence) and pooled specificity was 95% (89% to 96%), (low-certainty evidence), (7 studies, 3365 participants, 13% with tuberculosis).For a population of 1000 people where 100 have microbiologically-confirmed tuberculosis, the utilization of LF-LAM would result in: 80 to be LF-LAM positive: of these, 45 (56%) would not have tuberculosis (false-positives); and 920 to be LF-LAM negative: of these, 65 (7%) would have tuberculosis (false-negatives).By clinical setting, pooled sensitivity was 62% (41% to 83%) among inpatients versus 31% (18% to 47%) among outpatients; pooled specificity was 84% (48% to 96%) among inpatients versus 95% (87% to 99%) among outpatients.
|
31633805 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further spoligotyping analyses of the M. bovis and two available M. tuberculosis isolates classified the strains as SB1432 and SB09444 and LAM_10 CAM and T1 using respectively www.mbovis.org and spotclust databases.
|
22863763 |
2012 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The phylogenetic analysis showed that the LAM (16.7%) and Haarlem (15.7%) branches are the two most prevalent TB lineages circulating in Brussels.
|
28222189 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
After successful completion of anti-TB treatment at month 6, the levels of 16 kDa IgA and 16 kDa IgM dropped significantly whereas LAM IgG and TB-LTBI IgG increased.
|
28415587 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Available associated information on gender (n = 18,944), age (n = 16,968), drug resistance (n = 19,606), and HIV serology (n = 2673), allowed to draw some important conclusions on TB geo-epidemiology; e.g. a positive correlation exists between certain Mycobacterium tuberculosis lineages (such as CAS and Beijing) and drug resistance (p-value<.001), while other lineages (such as LAM, X, and BOV) are more frequently associated with HIV-positive serology (p-value<.001).
|
30593925 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other useful diagnostic tools at peripheral facilities include chest radiography, urine lipoarabinomannan (TB-LAM) in HIV-infected patients with advanced immunodeficiency, and the loop-mediated isothermal amplification (TB-LAMP) test which may be superior to smear microscopy.
|
30477096 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The M. tuberculosis population structure in Morocco is highly homogeneous, and is characterized by the predominance of the Euro-American lineages, namely LAM, Haarlem, and T, which belong to the "evolutionary recent" TbD1-/PGG2/3 phylogenetic group.
|
23077552 |
2012 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combining U-LAM with serum antibody detection could provide a simple low-cost method that meets the requirements for a non-sputum-based test for the screening of HIV-associated TB.
|
31237915 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
New Mycobacterium tuberculosis LAM sublineage with geographical specificity for the Old World revealed by phylogenetical and Bayesian analyses.
|
27865400 |
2016 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The WHO-endorsed immunodiagnostic Alere Determine Lipoarabinomannan Ag-test (LAM-test) detects Mycobacterium tuberculosis complex LAM in urine, and its use is recommended for TB diagnosis among HIV co-infected individuals with low CD4 T-cell counts.
|
31784649 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tuberculosis Case Finding With Combined Rapid Point-of-Care Assays (Xpert MTB/RIF and Determine TB LAM) in HIV-Positive Individuals Starting Antiretroviral Therapy in Mozambique.
|
29020319 |
2017 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we observed that the highest frequency of IMR-TB and MDR-TB strains belong to the LAM and Haarlem genotypes in Rio Grande do Sul state.
|
29779771 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show that T, Haarlem, and LAM are predominant lineages among clinical isolates of M. tuberculosis in Guadalajara, Mexico.
|
25695431 |
2015 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The high prevalence of Beijing and LAM in children with culture-confirmed TB reflects considerable transmission of these genotype families within the community.
|
16928967 |
2006 |