TSC2, TSC complex subunit 2, 7249

N. diseases: 410; N. variants: 317
Disease: Thyroid carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.320 Biomarker disease BEFREE Studies of mutations in the tumour suppressor genes <i>TSC1, TSC2,</i> and <i>STK11,</i> activating the mtor (mammalian target of rapamycin) pathway, might support their role in the pathogenesis of thyroid cancer. 29089812 2017
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.320 Biomarker disease BEFREE Additionally, knockdown of TSC2, the upstream regulatory molecule of mTOR pathway, or treatment of rapamycin, the mTOR inhibitor, could abolish the effects of metformin to regulate thyroid cancer cell proliferation, migration, EMT, and mTOR pathway molecules. 25854169 2015
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.320 CausalMutation disease CGI