|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Patients with MPS I, II, III, and VII can present with neurological manifestations such as neurocognitive decline and behavioral problems.
|
29153844 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NEK2 (p<0.001) and TTK (p = 0.002) expression in the noninvolved lung tissue was also associated with a 3-fold increased risk of mortality from lung adenocarcinoma in smokers.
|
18297132 |
2008 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Targeting dual specificity protein kinase TTK attenuates tumorigenesis of glioblastoma.
|
29423030 |
2018 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Modulation of miR-21 signaling by MPS1 in human glioblastoma.
|
25991676 |
2016 |
|
Adult Glioblastoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
However, high levels of Mps1 are found in many types of human malignancies, including glioblastoma, thyroid carcinoma, breast cancer, and other cancers.
|
27819146 |
2017 |
|
Adult Glioblastoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
High levels of Mps1 are found in various types of human malignancies, such as glioblastoma, osteosarcoma, hepatocellular carcinoma, and breast cancer.
|
30693152 |
2019 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
The effect of MPS1 inhibition was assessed in different orthotopic glioblastoma mouse models (n = 3-7 mice/group).
|
23940287 |
2013 |
|
Adult Glioblastoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Inhibition of MPS1 kinase in combination with radiation represents a promising new approach for glioblastoma and for other cancer therapies.
|
25722303 |
2015 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overall, these data demonstrate that the inhibition of Mps1 kinase using TC Mps1 12 is a promising therapeutic approach for liver cancer.
|
28299790 |
2017 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our data suggest that targeted TTK inhibition might have clinical utility as an adjunct therapy in management of liver cancer.
|
27618777 |
2016 |
|
Adult Lymphoblastic Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a sensitized p53(+/-) background we observed that Mps1(DK/DK) mice suffered from rapid-onset acute lymphoblastic lymphoma.
|
25197064 |
2014 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings highlight MPS1 as a rational therapeutic target for medulloblastoma.
|
27633003 |
2016 |
|
alpha-L-Iduronidase Deficiency
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
MPS I-H is the most severe form of alpha-l-iduronidase deficiency. alpha-l-iduronidase (encoded by the IDUA gene) is a lysosomal enzyme that participates in the degradation of dermatan sulfate and heparan sulfate.
|
19751987 |
2010 |
|
alpha-L-Iduronidase Deficiency
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that suppression therapy can attenuate the lysosomal storage disease mucopolysaccharidosis type I-Hurler (MPS I-H), the severe form of α-L-iduronidase deficiency.
|
24411223 |
2014 |
|
Alzheimer Disease, Early Onset
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Some studies have also reported that neurons containing AD-linked mutant presenilins (mPS1) show increased vulnerability to various stresses, while others report no differences in neuronal death.
|
17927985 |
2007 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We identified a 25 gene subset (PDAC CIN25) whose overexpression was most strongly correlated with poor survival and included MPS1.
|
24282275 |
2014 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We show that the dual specificity kinase TTK (also known as Mps1), is strongly overexpressed in human PDAC.
|
25137017 |
2014 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore we screened for mutations of the mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in six aneuploid bladder cancer cell lines and 15 human bladder tumours.
|
11323402 |
2001 |
|
Blindness
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The collective preclinical data demonstrate safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-associated cornea blindness.
|
26899286 |
2016 |
|
Brain Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Prevention of the immune response to enzyme may improve the efficacy of intrathecal enzyme replacement therapy for brain disease due to MPS I.
|
22402327 |
2012 |
|
Breast Cancer, Familial
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Neither the individual SNPs in the studied genes nor the haplotypes in the BUB1B, CENPE and TTK genes caused any significant effect on the risk of BC.
|
17268814 |
2007 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis.
|
31106147 |
2019 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
High levels of Mps1 are found in various types of human malignancies, such as glioblastoma, osteosarcoma, hepatocellular carcinoma, and breast cancer.
|
30693152 |
2019 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
These compounds were evaluated in anti-proliferative assays of a panel of 15 breast cancer cell lines and further examined for their ability to inhibit a variety of Mps1-dependent biological functions.
|
28259529 |
2017 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
These results point out TTK as a protein kinase overexpressed in TNBC that may represent an attractive therapeutic target specifically for this poor prognosis associated subgroup of breast cancer.
|
23700430 |
2013 |