Amyloidosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate if the type of amyloid fibril remains the same within ATTR Val30Met amyloidosis families.
|
30811423 |
2019 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Hereditary ATTR amyloidosis is an autosomal dominant genetic disorder with systemic deposition of amyloid fibrils induced by TTR gene mutation.
|
26306725 |
2015 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) is a rare, life-threatening disease, caused by point mutations in the transthyretin gene.
|
31445300 |
2019 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration in the brain.
|
27562180 |
2017 |
Amyloidosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Although not described previously, elevated IOP may develop in patients with vitreous amyloidosis due to a TTR Val30Gly mutation in the transthyretin gene.
|
17980738 |
2007 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Two types of TTR-associated amyloid cardiomyopathies are clinically important.
|
23716704 |
2013 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
A comprehensive computer literature search of studies published up to 30 November 2017 on the role of bone scintigraphy in patients with ATTR was performed using the following search algorithm: (a) "amyloid" OR "amyloidosis" AND (b) "TTR" OR "ATTR" OR "transthyretin" AND (c) "scintigraphy" OR "scan" OR "SPECT" OR "SPET" OR "bone" OR "skeletal" OR "skeleton" OR "PYP" OR "DPD" OR "HMDP" OR "MDP" OR "HDP".
|
29687207 |
2018 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Wild-type ATTR amyloidosis may be associated with unexpected death among the elderly.
|
31731233 |
2019 |
Amyloidosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Proportion between wild-type and mutant protein in truncated compared to full-length ATTR: an analysis on transplanted transthyretin T60A amyloidosis patients.
|
19118530 |
2009 |
Amyloidosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The development of autonomic dysfunction impacts morbidity, disease progression, and mortality in patients with hereditary ATTR amyloidosis.
|
31473866 |
2019 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Transthyretin familial amyloid polyneuropathy is a hereditary form of amyloidosis characterized by sensorimotor and autonomic neuropathy, cardiac conduction defects, and infiltrative cardiomyopathy.
|
23833285 |
2013 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Findings include poor outcome for AL-Am patients despite HTx and better survival for TTR-Am patients if HTx is associated with liver transplantation.
|
19459811 |
2009 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Transthyretin (TTR) is a serum protein that is also a prominent component of deposits in two different types of systemic amyloid disease, senile systemic and familial TTR amyloidoses.
|
17317215 |
2007 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
AG10 is a novel, potent, and selective oral transthyretin (TTR) stabilizer being developed to treat TTR amyloidosis (ATTR).
|
31172685 |
2020 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Novel methods for detecting amyloidogenic proteins in transthyretin related amyloidosis.
|
18508604 |
2008 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using a Drosophila model for TTR-associated amyloidosis, we found a new role for SAP as a protective factor in inhibition of TTR-induced toxicity.
|
23390551 |
2013 |
Amyloidosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This is the second report of transthyretin (TTR) amyloidosis in a patient who had ATTR Tyr114His diagnosed by mass spectrometry and gene analysis.
|
11409031 |
2001 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Besides the well-known mechanisms of immune activation and inflammation in atherosclerosis causing ischemic cardiomyopathy or myocarditis, attention is focused on other mechanisms leading to heart failure such as transthyretin (TTR) amyloidosis or heart failure with preserved ejection fraction.
|
31083399 |
2019 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Based on these findings, a novel model for transthyretin amyloid formation is presented.
|
11106758 |
2000 |
Amyloidosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Central nervous system (CNS) complications are increasingly noted in liver transplanted (LTx) hereditary transthyretin amyloid (ATTRm) amyloidosis patients; this suggests that the increased survival allows for intracranial ATTRm formation from brain synthesized mutant TTR.
|
29019809 |
2018 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The demonstration, by immunohistochemistry and laser micro dissection-mass spectrometry (LMD/MS) that the amyloid fibrils were composed of TTR, in conjunction with a typical FAP phenotype, indicates that the novel TTR mutation was the cause of amyloidosis.
|
25430583 |
2015 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutation in TTR causes a propensity of TTR tetramer to dissociate to monomer, which is the first step to amyloidosis.
|
26639444 |
2015 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Transthyretin amyloidosis (ATTR amyloidosis) is a rare disease characterised by extracellular deposition of amyloid fibrils composed by transthyretin.
|
30683924 |
2019 |
Amyloidosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Effect of nitric oxide in amyloid fibril formation on transthyretin-related amyloidosis.
|
16101296 |
2005 |
Amyloidosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Only one patient in our study had light chain amyloidosis and showed higher TBR than patients with transthyretin amyloid: TBR 3.0 versus TBR median 1.44, IQR 1.33-1.69.
|
31140154 |
2019 |