Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0205851
Disease: Germ cell tumor
Germ cell tumor
0.040 GeneticVariation disease BEFREE DSD patients with specific Y-chromosomal material in their karyotype, the GonadoBlastoma on the Y-chromosome (GBY) region, have an increased risk of developing type II germ cell tumors/cancer (GCC), most likely related to TSPY. 23157850 2012
CUI: C0205851
Disease: Germ cell tumor
Germ cell tumor
0.040 Biomarker disease BEFREE TSPY protein localized with established germ cell tumor markers, such as the placental alkaline phosphatase, c-KIT, and OCT3/4, in the same tumor cells of both gonadoblastoma and adjacent carcinoma in situ, the precursor for germ cell tumors. 17349529 2007
CUI: C0205851
Disease: Germ cell tumor
Germ cell tumor
0.040 Biomarker disease BEFREE The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. 17521702 2007
CUI: C0205851
Disease: Germ cell tumor
Germ cell tumor
0.040 AlteredExpression disease BEFREE Elevated levels of TSPY have been observed in gonadoblastoma specimens and a variety of other tumor tissues, including testicular germ cell tumors, prostate cancer, melanoma, and liver cancer. 16762081 2006