|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found only one mutation of the N-ras gene that was a 2-bp substitution of GGT(Gly) to GTC(Val) at codon 13 among 22 t(1;19)-ALL cases and five cell lines.
|
7727782 |
1995 |
|
Adenocarcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
He underwent left hemicolectomy, and histology diagnosed a well-differentiated, pT4, node-positive adenocarcinoma; KRAS analysis performed with direct sequencing identified a mutation in exon 2 of the KRAS gene (GGT->GTT).
|
28665451 |
2017 |
|
Adenomatous goiter
|
0.010 |
Biomarker
|
disease |
BEFREE |
A heterozygous mutation of codon 201 of Gs alpha (GGT [Arg]-CAT [His]) was observed in a nodule from an adenomatous goiter.
|
8501149 |
1993 |
|
Adrenoleukodystrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the G-allele of rs738409 was associated with a variety of clinical manifestations such as elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (GGT), and mean corpuscular volume (MCV) in the patients with ALD.
|
30132178 |
2018 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found only one mutation of the N-ras gene that was a 2-bp substitution of GGT(Gly) to GTC(Val) at codon 13 among 22 t(1;19)-ALL cases and five cell lines.
|
7727782 |
1995 |
|
Adult Leiomyosarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In these studies an activated K-ras gene that contained a mutation at the second position of codon 12 (GGT----GAT) was found in a leiomyosarcoma.
|
1923531 |
1991 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
From liver cancer to distal noncancerous tissues, an increasing tendency (P < 0.05) of total RNA concentrations was found; the frequencies of amplified fragment and hypomethylated M3 site of GGT genes were 100% and 75% in HCC, 85% and 55% in paracancerous tissues, and 75% and 50% in noncancerous tissues, respectively.
|
10679644 |
2000 |
|
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Applying this probe the GGT levels in human serum samples from both healthy and liver cancer patients have been readily detected; the results were consistent with those determined by an enzyme-linked immunosorbent assay.
|
31450413 |
2019 |
|
AICARDI-GOUTIERES SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
An appropriate medical evaluation and particular consideration of AGS is essential before surgical referral in infants with high GGT cholestasis.
|
20601899 |
2010 |
|
Alagille Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Alagille syndrome (AGS) frequently presents with neonatal jaundice and can mimic other causes of high gamma-glutamyl transpeptidase (GGT) cholestasis, most notably biliary atresia.
|
20601899 |
2010 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we determined how representative biological markers of alcoholism (gamma-glutamyltransferase [GGT], carbohydrate-deficient transferrin [CDT], and the mean corpuscular volume of erythrocytes [MCV]) differ with respect to the ALDH2 genotypes in Japanese habitual drinkers.
|
10803776 |
2000 |
|
Alzheimer disease, familial, type 3
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have observed a significant statistically decrease of GGT haplotype frequency (empirical p-value=0.0133 ); GAT haplotype was statistically significant increase in AD patients compared with control (empirical p-value=0.007).
|
26502815 |
2015 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
<b>Objectives:</b> The present study is geared to learning about the patterns of tau seeding and cells involved following unilateral inoculation in the corpus callosum of homogenates from sporadic Alzheimer's disease (AD), primary age-related tauopathy (PART: neuronal 4Rtau and 3Rtau), pure aging-related tau astrogliopathy (ARTAG: astroglial 4Rtau with thorn-shaped astrocytes TSAs), globular glial tauopathy (GGT: 4Rtau with neuronal tau and specific tau inclusions in astrocytes and oligodendrocytes, GAIs and GOIs, respectively), progressive supranuclear palsy (PSP: 4Rtau with neuronal inclusions, tufted astrocytes and coiled bodies), Pick's disease (PiD: 3Rtau with characteristic Pick bodies in neurons and tau containing fibrillar astrocytes), and frontotemporal lobar degeneration linked to P301L mutation (FTLD-P301L: 4Rtau familial tauopathy).
|
31191295 |
2019 |
|
Alzheimer's Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We have observed a significant statistically decrease of GGT haplotype frequency (empirical p-value=0.0133 ); GAT haplotype was statistically significant increase in AD patients compared with control (empirical p-value=0.007).
|
26502815 |
2015 |
|
Ameloblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Direct DNA sequencing showed a GGT to GCT point mutation at codon 12 of K-Ras gene in one ameloblastoma.
|
15200485 |
2004 |
|
Anthracosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, five HSP haplotypes of the HSP70 genes (namely GAT, GAC, GGT, CAC and CGT) were examined and the frequencies of haplotypes GAT and GGT were significantly higher in the CWP than in the control group.
|
21471543 |
2011 |
|
Arthrogryposis with renal dysfunction and cholestasis syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, this case indicates that ARC syndrome cannot be excluded from the differential diagnosis of neonatal cholestasis even if high GGT activity is found.
|
24782640 |
2014 |
|
Arthrogryposis with renal dysfunction and cholestasis syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome: a rare association with high GGT level and absent kidney.
|
30093463 |
2018 |
|
Arthrogryposis, renal dysfunction, and cholestasis 1
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Arthrogryposis, renal dysfunction and cholestasis (ARC) syndrome: a rare association with high GGT level and absent kidney.
|
30093463 |
2018 |
|
Arthrogryposis, renal dysfunction, and cholestasis 1
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, this case indicates that ARC syndrome cannot be excluded from the differential diagnosis of neonatal cholestasis even if high GGT activity is found.
|
24782640 |
2014 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Strong LD was found among rs678881, rs2280089 and rs2853209, and haplotype GGT was distinctly associated with the risk of asthma in children (OR = 0.28, 95%CI = 0.13-0.57).ADAM33 rs678881 polymorphism is significantly correlated with increased susceptibility to asthma in Chinese Han children.
|
31626088 |
2019 |
|
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Two H. pylori persistence determinants, the γ-glutamyl-transpeptidase GGT and the vacuolating cytotoxin VacA, are required and sufficient for asthma protection and can be administered in purified form to prevent asthma.
|
25074917 |
2014 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Older age and levels of UA, DBIL, and GGT influenced the occurrence of AF in thyrotoxic patients receiving RAI.
|
31725052 |
2019 |
|
Atypical Lipoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Age, ALT, and GGT were independent predictors of SLHC in HNALT patients, and age was the only independent predictor of SLHC in LNALT patients.
|
28245424 |
2017 |
|
Atypical Lipoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
At week 12 after end of therapy, ALT was elevated in 451/4946 (9.1%), ALT according to AASLD in 1906/4946 (38.5%) and GGT in 863/4879 (17.7%).
|
31241820 |
2020 |