|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA.
|
17241883 |
2007 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The variant genotypes of rs7763881 in HULC may contribute to decreased susceptibility to HCC in HBV persistent carriers.
|
22493738 |
2012 |
|
Tumor Cell Invasion
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
The higher expression of HULC was significantly correlated with large tumor size, advanced lymph node metastasis and vascular invasion.
|
25412939 |
2014 |
|
Secondary malignant neoplasm of lymph node
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The higher expression of HULC was significantly correlated with large tumor size, advanced lymph node metastasis and vascular invasion.
|
25412939 |
2014 |
|
Pancreatic carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results suggest that HULC may serve as a candidate prognostic biomarker through growth regulation in human PC.
|
25412939 |
2014 |
|
Malignant neoplasm of pancreas
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results suggest that HULC may serve as a candidate prognostic biomarker through growth regulation in human PC.
|
25412939 |
2014 |
|
Neoplasm Invasiveness
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.
|
26317792 |
2015 |
|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
|
26053186 |
2015 |
|
Smoking Behaviors
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
|
26053186 |
2015 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination of HULC and Linc00152 possessed a moderate ability to discrimination between HCC and control with an area under ROC value of 0.87 while the combination of AFP was 0.89 with a positive correlation with tissues expression.
|
26356260 |
2015 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cox regression analysis indicated that HULC was a positive factor for HCC overall survival (HR = 0.885, 95% CI = 0.797-0.983, and P = 0.023) and disease-free survival time (HR = 0.913, 95% CI = 0.835-0.998, and P = 0.045).
|
26136615 |
2015 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, HULC mRNA levels correlated positively with ACSL1 levels in 60 HCC cases according to real-time PCR analysis.
|
25592151 |
2015 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
HULC had a significant association with vascular invasion (OR = 0.648, 95% CI = 0.523-0.803, and P < 0.001).
|
26136615 |
2015 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that both plasma levels of HULC and Linc00152 achieve a fine diagnostic accuracy in diagnosing ontogenesis and metastasis of HCC and may act as novel biomarkers for HCC.
|
26356260 |
2015 |
|
Malignant neoplasm of esophagus
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer.
|
25874495 |
2015 |
|
Esophageal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer.
|
25874495 |
2015 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Circulation Tregs and HULC were significantly up-regulated in plasma samples of HBV-related cirrhosis patients.
|
25952928 |
2015 |
|
Esophageal carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer.
|
25874495 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have genotyped the ANRIL rs2151280 T/C, POLR2E rs3787016 C/T, and HULC rs7763881 A/C SNPs in 380 esophageal squamous cell carcinoma (ESCC) cases and 380 cancer-free controls.
|
25874495 |
2015 |
|
Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Circulation Tregs and HULC were significantly up-regulated in plasma samples of HBV-related cirrhosis patients.
|
25952928 |
2015 |
|
Malignant neoplasm of liver
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrate HULC, MALAT1 and TRF2 are highly expressed in human hepatocellular carcinoma tissues, and HULC plus MALAT1 overexpression drastically promotes the growth of liver cancer stem cells.
|
27782152 |
2016 |
|
Autosomal dominant compelling helio ophthalmic outburst syndrome
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HULC has been found to be up-regulated and acts as oncogene in gastric cancer and hepatocellular carcinoma, but its expression pattern, biological function and underlying mechanism in CRC is still undetermined.
|
27496341 |
2016 |
|
Tumor Cell Invasion
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner.
|
27809873 |
2016 |