|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study suggested that TNFSF4 rs1234315 and rs2205960 polymorphisms were associated with SLE susceptibility.
|
31299880 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also defined a novel HLA-DRA haplotype that confers an increased risk for lupus nephritis (LN) and alleles in HLA-DRA2 and TNFSF4 genes as genetic risk factors for developing neuropsychiatric (NP) SLE.
|
31032751 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results provided support for TNFSF4 rsl234315 as a SLE and RA susceptibility locus in a Chinese Guangxi population.
|
30468820 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data support that OX40L/OX40 signals are implicated in Treg dysfunction in human SLE.
|
30568041 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, single nucleotide polymorphisms in ITGAM, TNFSF4, TNFAIP3 and STAT4 genes are associated with susceptibility to SLE in a North Indian population.
|
30041578 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the contribution of Ox40L and its cognate receptor, Ox40, using in vivo agonist and antagonist approaches in the NZB × NZW (NZB/W) F1 mouse model of SLE.
|
28696253 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.600 |
Biomarker
|
disease |
BEFREE |
We further show that in two models of SLE-a spontaneous congenic model and the H2-IA<sup>bm12</sup> graft-versus-host-induced model-loss of B cell OX40L ameliorates the autoimmune phenotype.
|
28818832 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene encodes a vital co-stimulatory molecule of the immune system and has been identified as a susceptibility locus for systemic lupus erythematosus, systemic sclerosis, and primary Sjögren's syndrome.
|
29032462 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The frequency of minor T allele of TNFSF4 rs2205960 was significant in Chinese and Indian patients with SLE, with P values of 0.05 (OR = 1.27, 95% CI: 1.00-1.61) and 0.004 (OR = 3.16, 95% CI: 1.41-7.05), respectively.
|
27519474 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Polymorphisms in several genes were associated with IL-6 levels (including IL10, TYK2, and CD40L in SLE and DRB1, NOD2, and CSF1 in RA) or with TNFα levels (including TNFSF4 and CSF2 in SLE and PTPN2, DRB1, and NOD2 in RA).
|
25652333 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P(meta) = 1.08 × 10(-08); rs4916219, OR = 0.80, P(meta )= 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P(meta) = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P(meta) = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P(meta) = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P(meta) = 1.01 × 10(-09)).
|
25890262 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.
|
24091983 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results of our meta-analysis suggest that the TNFSF4 rs2205960 polymorphism may confer susceptibility to SLE in different populations and that the TNFSF4 rs1234315 polymorphism is associated with susceptibility to SLE in Asians.
|
22850862 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
Genetics and epigenetics of systemic lupus erythematosus.
|
23943494 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
The results of our meta-analysis suggest that the TNFSF4 rs2205960 polymorphism may confer susceptibility to SLE in different populations and that the TNFSF4 rs1234315 polymorphism is associated with susceptibility to SLE in Asians.
|
22850862 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that changes in the expression levels of TNFSF4 and TRAF2 mRNAs may significantly correlate with the pathogenesis of SLE, the disease activity and different clinical features of lupus, particularly lupus nephritis, atherosclerosis and arthritis.
|
22847298 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.
|
22654485 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
This meta-analysis confirms that TNFSF4 polymorphisms are associated with susceptibility to SLE in Asians and Europeans.
|
22820624 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Multiplicative interaction analysis indicated that BLK had an interactive effect with TNFSF4 in Chinese patients with SLE (P=6.57×10(-4)).
|
21905002 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The genetic variants of OX40L can increase the risk of SLE, atherosclerosis, systemic sclerosis and show gender-specific effects in some studies.
|
22870213 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
Multiplicative interaction analysis indicated that BLK had an interactive effect with TNFSF4 in Chinese patients with SLE (P=6.57×10(-4)).
|
21905002 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis confirms that TNFSF4 polymorphisms are associated with susceptibility to SLE in Asians and Europeans.
|
22820624 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study not only suggested that the TNFSF4 gene was associated with SLE in Chinese Han population, but also implied that it might be a common genetic factor predisposing to the development of SLE in multiple populations.
|
20012871 |
2011 |