TXNRD1, thioredoxin reductase 1, 7296

N. diseases: 136; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.310 Biomarker disease BEFREE Chemotherapeutic agents targeting FoxO3 and/or TR1, including AUR, might be promising adjuvant sensitizers to reverse chemoresistance in 5-FU-resistant CRC. 31811910 2020
CUI: C0001430
Disease: Adenoma
Adenoma
0.310 Biomarker group CTD_human Consistent with the individual SNP results, we observed a significant overall association with adenoma risk for SEPP1 and TXNRD1 (global P = 0.02 and 0.008, respectively) but not for the four GPX genes. 18483336 2008
CUI: C0001430
Disease: Adenoma
Adenoma
0.310 GeneticVariation group BEFREE Consistent with the individual SNP results, we observed a significant overall association with adenoma risk for SEPP1 and TXNRD1 (global P = 0.02 and 0.008, respectively) but not for the four GPX genes. 18483336 2008
CUI: C0001430
Disease: Adenoma
Adenoma
0.310 GeneticVariation group LHGDN Consistent with the individual SNP results, we observed a significant overall association with adenoma risk for SEPP1 and TXNRD1 (global P = 0.02 and 0.008, respectively) but not for the four GPX genes. 18483336 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.310 Biomarker disease CTD_human Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. 18483336 2008
CUI: C0011616
Disease: Contact Dermatitis
Contact Dermatitis
0.300 Biomarker disease CTD_human Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay. 25724174 2015
CUI: C0162351
Disease: Contact hypersensitivity
Contact hypersensitivity
0.300 Biomarker phenotype CTD_human Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay. 25724174 2015
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.300 Biomarker disease CTD_human Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. 19499324 2009
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.300 Biomarker disease CTD_human Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance. 18784066 2009
CUI: C0086237
Disease: Epilepsy, Cryptogenic
Epilepsy, Cryptogenic
0.300 Biomarker disease CTD_human Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. 19499324 2009
CUI: C0086743
Disease: Osteoarthrosis Deformans
Osteoarthrosis Deformans
0.300 Biomarker disease CTD_human Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance. 18784066 2009
CUI: C0236018
Disease: Aura
Aura
0.300 Biomarker phenotype CTD_human Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. 19499324 2009
CUI: C0751111
Disease: Awakening Epilepsy
Awakening Epilepsy
0.300 Biomarker disease CTD_human Changes in the expression of selenoproteins in mesial temporal lobe epilepsy patients. 19499324 2009
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.300 Biomarker group CTD_human Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. 18483336 2008
CUI: C0205646
Disease: Adenoma, Basal Cell
Adenoma, Basal Cell
0.300 Biomarker disease CTD_human Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. 18483336 2008
CUI: C0205647
Disease: Follicular adenoma
Follicular adenoma
0.300 Biomarker disease CTD_human Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. 18483336 2008
CUI: C0205648
Disease: Adenoma, Microcystic
Adenoma, Microcystic
0.300 Biomarker disease CTD_human Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. 18483336 2008
CUI: C0205649
Disease: Adenoma, Monomorphic
Adenoma, Monomorphic
0.300 Biomarker disease CTD_human Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. 18483336 2008
CUI: C0205650
Disease: Papillary adenoma
Papillary adenoma
0.300 Biomarker disease CTD_human Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. 18483336 2008
CUI: C0205651
Disease: Adenoma, Trabecular
Adenoma, Trabecular
0.300 Biomarker disease CTD_human Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. 18483336 2008
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.300 Biomarker disease CTD_human Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells. 17316382 2007
CUI: C0243038
Disease: Carcinoma, Lewis Lung
Carcinoma, Lewis Lung
0.300 Biomarker disease CTD_human Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. 16565519 2006
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.300 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.200 Biomarker disease RGD [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. 20571744 2010
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.200 Biomarker disease RGD Spinal ischemia/reperfusion injury resulted in a decrease in the expression of thioredoxin, while Buyang Huanwu Decoction administration greatly elevated the expression of thioredoxin-1/thioredoxin-2 mRNA and thioredoxin reductase-1/thioredoxin reductase-2 mRNA. 19409971 2009