Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The recent meta-analysis of GWAS has expanded the total number of RA-associated loci to more than 100, out of which approximately ∼97% (98 variants) loci are located in non-coding regions, and the other ∼3% (3 variants) are in three different non-HLA genes, i.e., TYK2 (Prp1104Ala), IL6R (Asp358Ala), and PTPN22 (Trp620Arg).
|
30899276 |
2019 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
BEFREE |
The search for inhibitors of the Janus kinase family (JAK1, JAK2, JAK3 and TYK2) has been ongoing for several decades and has resulted in a number of JAK inhibitors being approved for use in patients, such as tofacitinib for the treatment of autoimmune diseases such as Rheumatoid Arthritis (RA).
|
31288716 |
2019 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The FERM and pseudokinase domains in TYK2 were associated with the risk of RA in the Japanese population.
|
31118190 |
2019 |
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
BEFREE |
Selective inhibition of Tyk2 can provide pharmacological benefits in the treatment of many diseases such as psoriasis, systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), rheumatoid arthritis (RA), cancer, and diabetes.
|
30621465 |
2019 |
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
CTD_human |
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
|
30224649 |
2018 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
A significant association was detected between the GC genotype of rs34536443 (TYK2) in both the PsA and RA cohorts.
|
27440135 |
2017 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
BEFREE |
Together, our results demonstrate the role of TYK2 in the pathogenesis of RA, SLE and IBD, and provide supporting evidence for TYK2 as a promising drug target for the treatment of autoimmune diseases.
|
25849893 |
2015 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
BEFREE |
Therefore, single nucleotide polymorphisms of 14 genes involved in cellular adhesion processes (CAST, ITGA4, ITGB1, ITGB2, PECAM1, PTEN, PTPN11, PTPRC, PXN, SELE, SELP, SRC, TYK2, and VCAM1) were analyzed for association with RA.
|
25147926 |
2014 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.490 |
Biomarker
|
disease |
BEFREE |
Janus kinases (JAKs) are tyrosine kinases called JAK-1, JAK-2, JAK-3, and Tyk-2, which have been shown to participate in the signaling pathways of several cytokines that are believed to play a key role in several autoimmune-mediated disorders including rheumatoid arthritis (RA).
|
20724918 |
2011 |
Rheumatoid Arthritis
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
To determine whether genetic variants of the interferon regulatory factor 5 (IRF-5) and Tyk-2 genes are associated with rheumatoid arthritis (RA).
|
17599733 |
2007 |