TYK2, tyrosine kinase 2, 7297

N. diseases: 172; N. variants: 22
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 Biomarker disease BEFREE In addition, Tyk2-mediated signaling promoted the production of autoimmune-associated components, which is implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis. 24654603 2014
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 GeneticVariation disease GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 GeneticVariation disease BEFREE Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene. 22744673 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 Biomarker disease BEFREE This study replicated the genetic association of tyrosine kinase 2 with multiple sclerosis in a cohort of 1366 French patients and 1802 controls. 21354972 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 GeneticVariation disease BEFREE The highest association was at marker rs2304256 (odds ratio (OR) = 0.86; 95%CI = 0.82-0.90) in the TYK2 gene, which has previously been associated with systemic lupus erythematosus and multiple sclerosis. 19966805 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 GeneticVariation disease BEFREE A rare functional variant within the TYK2 gene (rs34536443) has been reported as protective in multiple sclerosis (MS) in recent studies. 19888296 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 Biomarker disease BEFREE CD6, CLEC16a, EVI5, GPC5, and TYK2 contained SNPs that are associated with MS risk in the African American data set. 19865102 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 Biomarker disease BEFREE The TYK2 gene, which also emerged in our analysis, has recently been associated with MS (Ban et al.2009). 20112030 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 Biomarker disease CTD_human We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001). 19525955 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 GeneticVariation disease BEFREE This single nucleotide polymorphism results in an amino acid substitution (proline to alanine) in the kinase domain of TYK2, which is predicted to influence the levels of phosphorylation and therefore activity of the protein and so is likely to have a functional role in multiple sclerosis. 19293837 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.490 GeneticVariation disease BEFREE We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001). 19525955 2009