|
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
|
Adverse reaction to drug
|
0.300 |
Biomarker
|
group |
CTD_human |
Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis.
|
21064136 |
2011 |
|
Adverse reaction to drug
|
0.300 |
Biomarker
|
group |
CTD_human |
Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway.
|
26077125 |
2016 |
|
Adverse reaction to drug
|
0.300 |
Biomarker
|
group |
CTD_human |
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
|
19648163 |
2009 |
|
Adverse reaction to drug
|
0.300 |
Biomarker
|
group |
CTD_human |
Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia.
|
25007187 |
2014 |
|
Anemia
|
0.320 |
Biomarker
|
disease |
CTD_human |
MTHFR 677C>T also increased the risk of leukopenia and gastrointestinal toxicity, whilst thymidylate synthase 28 bp repeat polymorphism increased the risk of anemia (odds ratio 8.48, 95% confidence interval 2.00-36.09).
|
19648163 |
2009 |
|
Brain Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity.
|
20714149 |
2010 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization.
|
21501481 |
2011 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
To test the hypothesis that polymorphisms of the TYMS gene are associated with risk of breast cancer, we genotyped these two polymorphisms in a case-control study of 432 incident cases with invasive breast cancer and 473 cancer-free controls in a Chinese population.
|
16723031 |
2006 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
|
19020767 |
2008 |
|
Cancer of Digestive System
|
0.300 |
Biomarker
|
disease |
CTD_human |
Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors.
|
18281538 |
2008 |
|
Cancer of Head
|
0.300 |
Biomarker
|
disease |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
|
19020767 |
2008 |
|
Cancer of Neck
|
0.300 |
Biomarker
|
disease |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
|
19020767 |
2008 |
|
Cleft Palate
|
0.310 |
Biomarker
|
disease |
CTD_human |
Folate pathway and nonsyndromic cleft lip and palate.
|
21254359 |
2011 |
|
Cleft palate, isolated
|
0.310 |
Biomarker
|
disease |
CTD_human |
Folate pathway and nonsyndromic cleft lip and palate.
|
21254359 |
2011 |
|
Cleft upper lip
|
0.310 |
Biomarker
|
disease |
CTD_human |
Folate pathway and nonsyndromic cleft lip and palate.
|
21254359 |
2011 |
|
Colonic Neoplasms
|
0.360 |
Biomarker
|
group |
CTD_human |
Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer.
|
18652704 |
2008 |
|
Colonic Neoplasms
|
0.360 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase messenger RNA expression in plasma from patients with colon cancer: prognostic potential.
|
16609021 |
2006 |
|
Colonic Neoplasms
|
0.360 |
Biomarker
|
group |
CTD_human |
Furthermore, four of them (one each from TYMS and PKG1 and two from AICRT/1) possessed the ability to induce HLA-A2-restricted and peptide-specific CTLs cytotoxic to colon tumor cells in peripheral blood mononuclear cells of colon cancer patients.
|
15355913 |
2004 |
|
Colonic Neoplasms
|
0.360 |
Biomarker
|
group |
CTD_human |
Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
|
16284371 |
2005 |
|
Colonic Neoplasms
|
0.360 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine.
|
19105824 |
2008 |
|
Colonic Neoplasms
|
0.360 |
Biomarker
|
group |
CTD_human |
Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer.
|
18192902 |
2008 |
|
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy.
|
16943523 |
2006 |
|
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.
|
25944804 |
2015 |
|
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.
|
19020767 |
2008 |