Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of TS mRNA were measured in 47 lung adenocarcinoma tissues using the Taq-Man real-time reverse transcriptase-polymerase chain reaction (RT-PCR) method and examined the clinicopathologic significance of TS expression.
|
16489621 |
2006 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, the measurement of TS mRNA in PBMNCs might aid the diagnosis of lung adenocarcinoma.
|
20494472 |
2011 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We measured TS expression in surgically resected pulmonary tumors, comparing HGNE carcinomas of the lung (13 large-cell neuroendocrine carcinomas, 8 small-cell lung carcinomas) with squamous cell carcinoma and adenocarcinoma of the lung using laser-capture microdissection for tissue isolation, real-time polymerase chain reaction (PCR), and immunohistochemistry.
|
20578072 |
2010 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lower TS expression in adenocarcinoma of the lung was confirmed in a large-scale study.
|
21321092 |
2011 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thymidylate synthase expression is known to be higher in squamous cell carcinoma than in adenocarcinoma of the lung.
|
22996376 |
2013 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of both TS protein and its mRNA was elevated in NSCLC tissues compared with matched normal tissues, and significantly higher in lung squamous cell carcinoma than in lung adenocarcinoma.
|
23350714 |
2013 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
TYMS copy numbers in lung adenocarcinoma cell lines were significantly lower than in squamous cell carcinoma (p=0.0105), and a significant correlation was found between the TYMS copy number and the 50% inhibitory concentration value for pemetrexed in all 17 lung cancer cell lines tested (r=0.6814, p=0.0026).
|
23645741 |
2013 |
Adenocarcinoma of lung (disorder)
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We assessed polymorphisms at 8 sites in 4 genes [thymidylate synthase (TS), dihydrofolate reductase (DHFR; 1610, 680, 317, intron 1), methylenetetrahydrofolate reductase (MTHFR; 677, 1298), glycinamide ribonucleotide formyl transferase (GARFT; 2255)] associated with pemetrexed metabolism using polymerase chain reaction, gene scanning, and restriction fragment length polymorphism analysis in 90 patients with adenocarcinoma of the lung.
|
23709418 |
2013 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicated that SUV(max) by ¹⁸F-FDG uptake may be an alternative biomarker for predicting TS expression in patients with primary lung adenocarcinoma, high-grade NE tumor, thymoma and MPM.
|
24173608 |
2014 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The median thymidylate synthase RNA level from 85 EML4-ALK+ cancers was significantly lower compared with that of EML4-ALK-negative lung adenocarcinomas (2.02 versus 3.29, respectively, p<0.001).
|
24346090 |
2014 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of TYMS protein and mRNA expression, reduced TYMS activity, and suppressed E2F1 expression were demonstrated in lung adenocarcinoma with ATO.
|
24691991 |
2014 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Arsenic trioxide (ATO) has been shown to suppress thymidylate synthase (TYMS) in lung adenocarcinoma and colorectal cancer, and induce apoptosis in acute promyelocytic leukemia.
|
25335113 |
2015 |
Adenocarcinoma of lung (disorder)
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was no significant association between the TYMS polymorphisms and the risk of lung adenocarcinoma.
|
25536611 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the H-score of thymidylate synthase was not associated with the response to pemetrexed therapy in patients with different molecular subtypes of lung adenocarcinoma.
|
27094798 |
2016 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
Adenocarcinoma of lung (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated whether AEG-1 expression level correlated with that of thymidylate synthase (TS), as higher TS expression is known to be associated with the resistance to pemetrexed chemotherapy in patients with advanced lung adenocarcinoma.
|
28977913 |
2017 |
Adenocarcinoma of lung (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Deciphering Clinicoradiologic Phenotype for Thymidylate Synthase Expression Status in Patients with Advanced Lung Adenocarcinoma Using a Radiomics Approach.
|
29895834 |
2018 |