TYMS, thymidylate synthetase, 7298

N. diseases: 406; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034885
Disease: Rectal Neoplasms
Rectal Neoplasms
0.320 Biomarker group CTD_human Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy. 16931962 2006
CUI: C0034885
Disease: Rectal Neoplasms
Rectal Neoplasms
0.320 Biomarker group BEFREE High TS was only found in 9.3% of rectal tumors, but in 29.7% of colon cancers (p=0.0042). 23968134 2013
CUI: C0034885
Disease: Rectal Neoplasms
Rectal Neoplasms
0.320 GeneticVariation group BEFREE Germline thymidylate synthase and XRCC1 polymorphisms might be useful as predictive markers of rectal tumor response to neoadjuvant chemoradiotherapy with 5-fluorouracil. 21167658 2012