UBE2B, ubiquitin conjugating enzyme E2 B, 7320

N. diseases: 59; N. variants: 0
Disease: Cervix carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.060 Biomarker disease BEFREE The HPV16 E2 protein plays an important role in tumourigenicity of cervical carcinoma. 30008422 2018
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.060 AlteredExpression disease BEFREE Using new polyclonal antibodies against the HPV16 E2 protein, we showed that E2 is expressed at various precursor stages of cervical carcinoma by immunohistochemistry on paraffin-embedded clinical samples. 20530671 2010
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.060 Biomarker disease BEFREE Diffusible VP22-E2 protein kills bystander cells and offers a route for cervical cancer gene therapy. 16454648 2006
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.060 AlteredExpression disease BEFREE A hallmark of HPV-associated cervical carcinoma is loss of the expression of the viral E2 protein, often by disruption of E2-encoding gene. 14871818 2004
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.060 Biomarker disease BEFREE Our results suggest that local delivery of VP22-E2 fusion proteins could be used to treat cervical cancer and other HPV-associated diseases. 14709162 2004
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.060 Biomarker disease BEFREE Thus, a number of cervical carcinoma cell lines are remarkably sensitive to growth inhibition by the E2 protein. 8389903 1993