Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The knockdown of the UCH-L1 in <i>Drosophila</i> can be used in studying the epidemiology of the disease as well as in drug screening for finding therapeutic targets for PD.
|
31585883 |
2020 |
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This suggests that pink1, atp13a2 and uchl1 expressions are regulated by inflammation, and this regulatory mechanism might be involved in the progress of PD.
|
31201839 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistic studies in mice suggest the existence of multiple molecular contributors to the neuroprotective effects of NAPE-PLD deletion, including suppression of Rac1 activity and attenuated transcription of several genes (Cadps, Casp9, Egln1, Kcnj6, Spen, and Uchl1) implicated in dopamine neuron survival and/or Parkinson's disease.
|
31685899 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings, while drawn from a relatively small sample size, suggest that deregulation of APA may play a significant role in neurodegeneration by altering the expression of genes including UBR1 and OGDHL in AD, LONP1 in PD and UCHL1 in ALS.
|
31072331 |
2019 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We herein modeled the study of UCHL1 in Drosophila melanogaster and investigated its functions in PD.
|
29535397 |
2018 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, a Parkinson's disease related mutant UCHL1 I93 M defects its DUB activity and can no longer inhibit autophagosome formation.
|
29462615 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we demonstrated that UCH-L1 associates with lipid rafts as with other PD-associated gene products.
|
30429647 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found connections between copper dyshomeostasis and the UCHL1/PARK5 pathway of Parkinson disease, which we validated with mitochondrial respiration and Drosophila genetics assays.
|
29397366 |
2018 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we summarize the effect of these genetic mutations and post-translational modifications on the association of UCHL1 and PD in terms of loss of cellular functions or gain of cellular toxicity.
|
26899237 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results indicate that the significant DEGs, including UCHL1, PDPK1 and PRKACB may be associated with the development of PD.
|
28765971 |
2017 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report here that UCHL1 undergoes S-nitrosylation in vitro and rotenone induced PD mouse model.
|
28300150 |
2017 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a key neuronal deubiquitinating enzyme which is mutated in Parkinson disease (PD) and in childhood-onset neurodegenerative disorder with optic atrophy.
|
25403879 |
2015 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our meta-analysis suggests that UCHL1 S18Y polymorphism is moderately associated with susceptibility to PD, and more studies are needed to confirm our conclusion.
|
25370916 |
2015 |
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that NT-UCH-L1 may have the potential to prevent neural damage in diseases like PD.
|
24959670 |
2014 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this is the latest and largest meta-analysis assessing the association of the UCHL-1 S18Y variant with the risk of PD in Asian ancestry.© 2014 S. Karger AG, Basel.
|
25471998 |
2014 |
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We identified that elevated alpha-synuclein messenger RNA levels in SN DA neurons of human PD brains were positively correlated with corresponding elevated levels of mRNAs for functional compensation of progressive SN DA loss and for enhanced proteasomal (PARK5/UCHL1) and lysosomal (PARK9/ATPase13A2) function, possibly counteracting alpha-synuclein toxicity.
|
24742361 |
2014 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the current meta-analysis suggests no evidence for the association between the UCHL1 S18Y polymorphism and PD risk in the Asian population, especially in subgroups of ethnicity and age at onset.
|
25354657 |
2014 |
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, in the context of a-syn-induced pathology, modulation of UCH-L1 activity could serve as a therapeutic tool to enhance the autophagy pathway and induce clearance of the observed accumulated/aggregated a-syn species in the PD brain.
|
22514658 |
2012 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia.
|
22688354 |
2012 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were no significant interactions between UCHL1 S18Y and smoking or caffeine intake affecting sporadic PD.
|
22839974 |
2012 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, these data provide evidence for an antioxidant and neuroprotective effect of the S18Y variant of UCH-L1, but not of the WT protein, in the dopaminergic system, and may have implications for the pathogenesis of PD or related neurodegenerative conditions, in which oxidative stress might play a role.
|
22076440 |
2012 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In several previous studies, an S18Y (C54A) polymorphism in exon 3 of the UCH-L1 gene has been found to be protective against PD.
|
21315600 |
2011 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The effect of Parkinson's-disease-associated mutations on the deubiquitinating enzyme UCH-L1.
|
21251915 |
2011 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To further explore the role of UCHL1 in PD, we genotyped S18Y in 605 PD patients and 1620 controls of Japanese ancestry.
|
21345711 |
2011 |
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that the Parkinson's disease-associated mutation I93M in UCH-L1 decreased the secretion of I93M UCH-L1.
|
21693148 |
2011 |