|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcriptome analysis identified the gene networks modulated by HDAC4 in ALS, revealing UCP1 as a top regulator that may be implicated in worsening ALS features.
|
30713114 |
2019 |
|
Cachexia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Parathyroid hormone appears to also be a potent regulator of BAT activity and may be an important mediator of elevated expenditure during cancer cachexia, although this is disputed by observations that cachexia wasting is not blunted in UCP1 KO mice.
|
31325458 |
2019 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, high UCP1 expression in the PAT may serve as an indicator of poor prognosis in RCC.
|
31545449 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of brown fat-associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis.
|
30737786 |
2019 |
|
Diphtheria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To overcome this, Ucp1-Cre was used to drive diphtheria toxin expression in cells expressing UCP1 (Ucp1<sup>Cre+/DTA+</sup>).
|
31758074 |
2019 |
|
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression.
|
30903204 |
2019 |
|
Hyperthyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consequently, the metabolic and thermogenic effects of systemic hyperthyroidism were maintained in UCP1 knockout mice, demonstrating that neither beige nor brown fat contributes to the TH-induced hyperthermia and elevated glucose consumption, and underlining that the mere presence of UCP1 is insufficient to draw conclusions on the therapeutic potential of browning agents.
|
31189119 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Deletion of UCP1 increased oxidative stress in kidneys and aggravated ischemia or cisplatin induced AKI in mice.Viral-based overexpression of UCP1 reduced mitochondrial ROS generation and apoptosis in hypoxia-treated tubular epithelial cells.
|
31678001 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
HBx promotes cellular proliferation and metastasis via UCP.
|
30903204 |
2019 |
|
Essential Hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest haplotypes of UCP1-3 genes are linked to EH risk in a northeastern Han Chinese population.
|
30518806 |
2019 |
|
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Stem cell-derived adipocytes exposed to caffeine (1 mM) showed increased UCP1 protein abundance and cell metabolism with enhanced oxygen consumption and proton leak.
|
31235722 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UCP was more frequently expressed in HBV-positive liver cancers than in HBV-negative liver cancers.
|
30903204 |
2019 |
|
Acute Chest Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
EAT PGC1α and UCP1 gene expression levels also decreased in the ACS group.
|
31102956 |
2019 |
|
metabolic disturbance
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A daily intake of chromium supplements increased tissue chromium levels and thermogenic uncoupling protein-1 (UCP-1) expression in white adipose tissues, as well as improved both post-olanzapine weight gain and metabolic disturbance.
|
30717287 |
2019 |
|
SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Generating human white Simpson-Golabi-Behmel syndrome (SGBS) adipocytes with a stable knockout and overexpression of UCP1, we discovered that UCP1 overexpressing adipocytes significantly improve glucose uptake by 40%.
|
31382214 |
2019 |
|
Catabolic state
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here, we demonstrate that melatonin activates transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1A (PGC1A) and uncoupling protein 1 (UCP1)-dependent lipid autophagy and a lipid browning program to elicit a catabolic state called "tumor slimming," thus suppressing tumor progression.
|
31469445 |
2019 |
|
Hepatocarcinogenesis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, it remains unknown whether HBx modulates the enzyme activity of UCP and thereby influences hepatocarcinogenesis.
|
30903204 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed expression of uncoupling protein 1 (UCP1) in SAT exposed to PDAC exosomes, SAT from mice with PDACs, and SAT from all 5 patients but only 1 of 4 controls.
|
30677401 |
2019 |
|
Premature coronary artery atherosclerosis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD).
|
29786102 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression.
|
30903204 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of brown fat-associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis.
|
30737786 |
2019 |
|
Lecithin Acyltransferase Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Primed expression of PRDM16 and UCP in quiescent satellite cell caused by LCAT deficiency synergizes with cell cholesterol depletion to induce satellite cell-to-BAT transdifferentiation.
|
29369831 |
2018 |
|
Thromboangiitis Obliterans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
With the addition of bimatoprost, types 1 and 2 TAO and control adipocytes exhibited a significant decrease in lipid content with morphologic transformation into smaller and multilocular lipid droplets, and an increase in mitochondrial load and UCP-1 expression consistent with an increase in brown adipose tissue turnover.
|
30551199 |
2018 |
|
Hypocholesterolemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Primed expression of PRDM16 and UCP in quiescent satellite cell caused by LCAT deficiency synergizes with cell cholesterol depletion to induce satellite cell-to-BAT transdifferentiation.
|
29369831 |
2018 |
|
Suprascapular nerve compression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice.
|
30020151 |
2018 |