|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Decreased UCP2 gene expression in mononuclear cells from obese and diabetic patients might contribute to the immunological abnormalities in these metabolic disorders and suggests its role as a candidate gene in future studies of obesity and diabetes.
|
29151065 |
2017 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We also tested for an effect of the P12A variant of the peroxisomal proliferator-activated receptor-gamma 2 (PPAR gamma 2) gene on diabetes risk given by the UCP2 SNP.
|
15562023 |
2005 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A variant in the promoter of the human uncoupling protein 2 (UCP2) gene, the G-866A polymorphism, has been associated with future risk of coronary heart disease events, in those devoid of traditional risk factors and in those suffering from diabetes.
|
19527523 |
2009 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Inactivation of the Ucp2 gene, which is expressed in the pancreatic beta-cells, resulted in increased islet ATP, increased serum insulin levels, and suppression of the diabetes of the ob/ob mouse genotype.
|
12013805 |
2002 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We investigated the association of the commonly observed UCP2 Ala55Val (V) polymorphism with diabetes mellitus and impaired fasting glucose (IFG) among 3684 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
|
15951317 |
2005 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
UCP2 has been shown to play an important role in obesity and diabetes.
|
24440978 |
2013 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans.
|
19413708 |
2009 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings suggest a role of UCP2-UCP3 gene cluster haplotypes in diabetes; in particular, the effects of the high-risk haplotypes were more apparent in overweight Caucasian women.
|
18223008 |
2008 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The mitochondrial protective gene PGC-1α is also closely related to diabetes, and UCP2 is related to anti-mitochondrial oxidative stress, but the mechanism of action of these genes is unclear.
|
26315270 |
2015 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the uncoupling protein 3 (UCP3) gene with obesity and diabetes related traits in subjects with impaired glucose tolerance participating in Finnish Diabetes Prevention Study.
|
19769793 |
2009 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, these data suggest that miR-214 regulates diabetes through a ROS/Akt/mTOR signaling pathway by UCP2 in proximal tubular cells.
|
30988734 |
2019 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic mutations of UCP2 may not be commonly associated with obesity or diabetes in Japanese subjects.
|
10337857 |
1999 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
UCP2 expression levels have been linked to predisposition to diabetes and obesity.
|
16021520 |
2005 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The UCP2-UCP3 gene region has been previously associated with obesity and diabetes.
|
11126413 |
2000 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To test this hypothesis we searched for association between the A-->G (-3862) variant in UCP1, the insertion/deletion (I/D) polymorphism in exon 8 in UCP2, and the C-->T (-55) polymorphism in UCP3 and diabetic nephropathy in 218 diabetic patients with normal urinary albumin excretion rate (AER), 216 with micro- or macroalbuminuria, and in 106 control subjects without a family history of diabetes.
|
15120704 |
2004 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Pathological UCP2 expression or activation may suppress glucose-stimulated insulin secretion to the extent that diabetes onset is hastened.
|
17052202 |
2006 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, rs659366-AA at UCP2 and rs15673-TT at UCP3 were correlated to diabetes in a small sub-group of patients.
|
28281015 |
2017 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our aims are to evaluate the interaction between LTL and UCP2 polymorphisms in 950 subjects without diabetes.
|
27615599 |
2016 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Polymorphisms in the mitochondrial membrane transporter gene UCP2 are capable of affecting energy metabolism, body weight regulation, and possibly preventing the buildup of reactive oxygen species, all factors that could contribute to neural tube defect risk through maternal obesity and diabetes.
|
12797456 |
2003 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
UCP2 and UCP3 could therefore have an important role in body weight regulation and susceptibility to diabetes.
|
10382588 |
1999 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The presence of a mixed genetic background in most published studies of UCP2 or UCP3 gene-ablated mice also means that data concerning marked differences in diabetes propensity, infection sensitivity and production of reactive oxygen species may require confirmation in backcrossed mice.
|
12525856 |
2003 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
UCP-2 can possibly modify atherosclerotic processes initiated in vascular cells and agents that increase UCP-2 expression in vascular cells may help prevent the development and progression of atherosclerosis in patients with diabetes or hypertension.
|
17462780 |
2007 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
UCP2 -866G>A (rs659366) has been implicated in cardiometabolic disease and represents a novel candidate gene for beta-blocker response, particularly among patients with diabetes.
|
20145583 |
2010 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear.
|
22461387 |
2012 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, our results shed further light on the regulatory network in β-cells consisting of miRNAs, UCP2, and insulin and provide novel therapeutic targets for diabetes.
|
30007975 |
2018 |