UCP2, uncoupling protein 2, 7351

N. diseases: 235; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 Biomarker group BEFREE Despite a mild pulmonary hypertension in UCP2-/- mice, hearts from these mice are well preserved against additional pressure overload (severe pulmonary hypertension). 30850841 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 AlteredExpression group BEFREE Conclusions The deletion of DJ -1 leads to oxidative stress-induced hypertension associated with downregulation of NO function, and overexpression of Ucp2 in the kidney increases blood pressure in DJ -1 <sup>-/-</sup> mice. 30995881 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 AlteredExpression group BEFREE The expression of UCP2 in proximal tubular cells may explain their relative propensity to damage in pathological conditions including the hypertensive disease. 29936692 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 Biomarker group BEFREE The UCP2 gene downregulation is a key determinant of higher predisposition to renal and cerebrovascular damage in an animal model of spontaneous hypertension and stroke. 29163755 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 Biomarker group BEFREE This study investigated whether UCP2 and associated oxidative stress reduction contribute to the improvement of endothelial function by a dipeptidyl peptidase-4 inhibitor, sitagliptin, in hypertension. 24328731 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 Biomarker group BEFREE Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. 22461387 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 Therapeutic group RGD Oral intake of rosiglitazone promotes a central antihypertensive effect via upregulation of peroxisome proliferator-activated receptor-gamma and alleviation of oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats. 20404217 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 AlteredExpression group BEFREE UCP-2 can possibly modify atherosclerotic processes initiated in vascular cells and agents that increase UCP-2 expression in vascular cells may help prevent the development and progression of atherosclerosis in patients with diabetes or hypertension. 17462780 2007
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 Biomarker group CTD_human Contribution of reactive oxygen species to the pathogenesis of left ventricular failure in Dahl salt-sensitive hypertensive rats: effects of angiotensin II blockade. 16685210 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 AlteredExpression group BEFREE Our data suggest that agents increasing UCP-2 expression in vascular cells may help prevent the development and progression of atherosclerosis in patients with diabetes and hypertension. 15827742 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 GeneticVariation group BEFREE A common polymorphism of uncoupling protein 2 gene is associated with hypertension. 15106800 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.590 GeneticVariation group LHGDN To clarify the contribution of this polymorphism to obesity and related conditions, we studied the association of the -866 G/A polymorphism of the UCP2 gene with obesity, hypertension and type 2 diabetes mellitus. 15106800 2004