|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present review summarizes the latest findings of UCP2 with respect to obesity, diabetes and cancer.
|
31330574 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding.
|
31495690 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms of UCP2 exon 8 del/ins and UCP3-55C/T did not influence obesity risk (p > 0.05).
|
28704105 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Previous work has demonstrated that deletion of the adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via upregulation of the uncoupling protein 2 (UCP2).
|
27795298 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Decreased UCP2 gene expression in mononuclear cells from obese and diabetic patients might contribute to the immunological abnormalities in these metabolic disorders and suggests its role as a candidate gene in future studies of obesity and diabetes.
|
29151065 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Upregulation of uncoupling protein 2 (UCP2) is associated with impaired glucose-stimulated insulin secretion (GSIS), which is thought to be an important contributor to pathological β cell failure in obesity and type 2 diabetes (T2D); however, the physiological function of UCP2 in the β cell remains undefined.
|
28702331 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Loss of FABP4 in peripheral macrophages via either molecular or pharmacologic mechanisms results in reduced obesity-induced inflammation via a UCP2-redox based mechanism.
|
28214555 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present article, we will review the evidence that UCP2, as a consequence of its roles within the mitochondria, represents a critical player in the predisposition to vascular disease development in both animal models and in humans, particularly in relation to obesity, diabetes, and hypertension.
|
29163755 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The UCP-2 exon 8 del/ins polymorphism was associated with higher degree of obesity, insulin resistance, dyslipideamia and lower adjusted metabolic rate.
|
25081806 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To test this hypothesis, we investigated the interaction between tagging polymorphisms in the UCP2 gene (rs2306819, rs599277 and rs659366), alcohol intake and obesity traits such as BMI and waist circumference (WC) on alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) in a large meta-analysis of data sets from three populations (n=20 242).
|
26526553 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.
|
24752406 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index.
|
24827746 |
2014 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
JZ expression of thyroid hormone signaling components Trh, Dio2, Trα, and Ucp2 were negatively associated with maternal leptin. mRNA expression of TRH, TRβ and UCP1 were also decreased in term placenta from OB women.
|
25449029 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To assess the relation of UCP2 -866G/A polymorphism and obesity susceptibility, a meta-analysis was performed.
|
23147265 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Common polymorphisms of the UCP-2 gene might influence the propensity to overweight/obesity in Hungarian children.
|
23432701 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
UCP2 has been shown to play an important role in obesity and diabetes.
|
24440978 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
UCP2 I/D polymorphism showed an association with obesity.
|
23314523 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
But neither the UCP2 Ala55Val nor the UCP3 -55C/T polymorphism showed any significant association with obesity risk in either subjects of Asian (REM OR = 0.84, 95% CI: 0.67-1.06 for Ala55Val; REM OR = 0.94, 95% CI: 0.55-1.28 for -55C/T) or of European descent (REM OR = 1.04, 95% CI: 0.80-1.36 for Ala55Val; FEM OR = 1.08, 95% CI: 0.97-1.20 for -55C/T).
|
23560041 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found no consistent associations between the UCP2 -866G-allele and obesity or type 2 diabetes.
|
22349573 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear.
|
22461387 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate the potential association of the uncoupling protein-2 (UCP2) 45-bp insertion/deletion (ins/del) polymorphism with obesity, as well as the potential effect of this polymorphism on weight loss variability in severely obese subjects.
|
22568573 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A 45-bp insertion/deletion polymorphism in uncoupling protein 2 is not associated with obesity in a Chinese population.
|
22733179 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the association of commonly observed UCP2 G(-866)A (rs659366) and Ala55Val (C > T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population.
|
22533685 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study shows association between the UCP2 gene and the susceptibility to obesity and body fat distribution in a south European population.
|
21883184 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The authors investigated 23 single nucleotide polymorphisms among 9 genes (ADRB3, ENPP1, FTO, LEP, PPARG, PPARGC1A, SLC2A2, TCF7L2, and UCP2) associated with type 2 diabetes or obesity.
|
23132673 |
2012 |