UCP2, uncoupling protein 2, 7351

N. diseases: 235; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 AlteredExpression disease BEFREE In vitro, CVC inhibited CCL2-induced increases in hepatocyte fatty acid synthase (Fasn) and adipose differentiation-related protein (Adrp), whereas it augmented acyl-coenzyme A oxidase 1 (Acox-1), proliferator-activated receptor gamma co-activator alpha (Pgc1α) and uncoupling protein 2 expression, suggesting mechanisms for attenuated hepatocyte steatosis. 30179264 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 AlteredExpression disease BEFREE Oxidative stress and mitochondrial uncoupling protein 2 expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats. 31022254 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 AlteredExpression disease BEFREE Combined exposure to NP and HSHFD induced macrovesicular steatosis with dilation and congestion of the central vein, liver inflammatory cell infiltration, and expression of genes regulating lipid metabolism, SREBP-1C, FAS, and Ucp2. 29459774 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 AlteredExpression disease BEFREE Severe liver steatosis with down-regulation of PPAR-α and UCP2 and up-regulation of SREBP-1c, IL-6 and SOD-1 was observed in the female offspring born to deficient dams. 28219837 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 AlteredExpression disease BEFREE We conclude that TRPV1 long-time activation might prevent high-fat diet-induced fatty liver in mice through upregulation of hepatic UCP2. 22395410 2012
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease BEFREE UCP2 is a recently identified fatty acid-responsive mitochondrial inner membrane carrier protein showing wide tissue distribution with a substantially increased presence in fatty liver. 15970480 2005
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.360 Biomarker disease CTD_human Mitochondrial adaptations to obesity-related oxidant stress. 10860543 2000