|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, using the quantitative transmission disequilibrium test (QTDT), we assessed linkage and association between the UCP3 gene and obesity phenotypes in a large sample of 1,873 subjects from 405 United States Caucasian nuclear families.
|
15870396 |
2005 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects.
|
16631432 |
2006 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the LEP and UCP2/UCP3 genes are unlikely to have a substantial effect on variation in obesity phenotypes in this particular US Caucasian population.
|
15910756 |
2005 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.
|
24752406 |
2014 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the influence of -55CT polymorphism of the UCP3 gene on insulin concentrations and metabolic parameters secondary to two hypocaloric diets in obese patients.
|
18825612 |
2009 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here we tested the hypothesis that variation of the UCP3 promoter is associated with either juvenile or maturity-onset obesity or body weight change over a 26-yr follow-up among Danish subjects.
|
11238538 |
2001 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We identified four novel mutations in the UCP3 gene (V56M, A111V, V192I and Q252X) in 200 children with severe, early-onset obesity (body mass index-standard deviation score >2.5; onset: <4 years) living in Southern Italy.
|
21544083 |
2012 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population.
|
18249216 |
2008 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude it is unlikely that variants in the coding region of the UCP3 gene contribute to the pathogenesis of juvenile-onset obesity among Danish Caucasians.
|
9498661 |
1998 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
But neither the UCP2 Ala55Val nor the UCP3 -55C/T polymorphism showed any significant association with obesity risk in either subjects of Asian (REM OR = 0.84, 95% CI: 0.67-1.06 for Ala55Val; REM OR = 0.94, 95% CI: 0.55-1.28 for -55C/T) or of European descent (REM OR = 1.04, 95% CI: 0.80-1.36 for Ala55Val; FEM OR = 1.08, 95% CI: 0.97-1.20 for -55C/T).
|
23560041 |
2013 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The V-A-T haplotype within UCP2-UCP3 gene cluster is also significantly associated with obesity in Paiwan aborigines.
|
17502873 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A variant in the putative promoter region of UCP3 (-55 c-->t) has recently been identified, and an association with obesity reported in French subjects.
|
11151767 |
2000 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
RETRACTED: Association between peroxisome proliferator-activated receptor, UCP3 and lipoprotein lipase gene polymorphisms and obesity in Chinese adolescents.
|
26483159 |
2017 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, central obesity in whites as reflected by an increased waist-to-hip ratio is associated with the UCP-1 Ala64Thr and UCP-3 C-55T polymorphisms.
|
12756473 |
2003 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of UCP-3 rs1626521 with obesity and stomach functions in humans.
|
25755013 |
2015 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine whether there is an association between the UCP2/UCP3 locus and the obesity in the Japanese population when using a single nucleotide polymorphism (SNP)-based and haplotype-based case-control study with gender-specific analysis.
|
18956255 |
2009 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms of UCP2 exon 8 del/ins and UCP3-55C/T did not influence obesity risk (p > 0.05).
|
28704105 |
2017 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The UCP3 variant was not significantly associated with metabolic rate or obesity.
|
9700198 |
1998 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Combinatory genotype analysis showed that BMI and TBF were significantly different among UCPI -3826A/G and UCP3 -55C/T genotype combinations, suggesting the existence of a gene interaction between UCP1 and UCP3 in influencing obesity and adiposity.
|
25812254 |
2015 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
With the capacity to participate in thermogenesis and energy balance, UCP3 is an important obesity candidate gene.
|
9769326 |
1998 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents.
|
17870627 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
UCP3 -55C>T polymorphism carriers have apparently a lower risk of obesity when taking into consideration recreational energy expenditure.
|
16006788 |
2005 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Like its close relatives UCP1 and UCP3, UCP2 uncouples proton entry in the mitochondrial matrix from ATP synthesis and is therefore a candidate gene for obesity.
|
11381268 |
2001 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
UCP3-55C/T and the RPTOR-26934C/T may only have subtle effects on the development of obesity-related traits in the present humans.
|
25533680 |
2014 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Two recently described proteins in the mitochondrial uncoupling protein (UCP) family, UCP-2 and UCP-3, have been linked to phenotypes of obesity and NIDDM.
|
9726246 |
1998 |