|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Hypocaloric diet reduces UCP3 expression in individuals with obesity and the UCP3, PLIN1 and PPARG2 expression correlate positively with carbohydrate oxidation and negatively with lipid oxidation.
|
28651828 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
RETRACTED: Association between peroxisome proliferator-activated receptor, UCP3 and lipoprotein lipase gene polymorphisms and obesity in Chinese adolescents.
|
26483159 |
2017 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms of UCP2 exon 8 del/ins and UCP3-55C/T did not influence obesity risk (p > 0.05).
|
28704105 |
2017 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of UCP-3 rs1626521 with obesity and stomach functions in humans.
|
25755013 |
2015 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Trim30 and Ucp3 might be used as genetic markers to precisely represent the stage of obesity during the early and late stages of adipose tissue development, respectively.
|
25895476 |
2015 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Combinatory genotype analysis showed that BMI and TBF were significantly different among UCPI -3826A/G and UCP3 -55C/T genotype combinations, suggesting the existence of a gene interaction between UCP1 and UCP3 in influencing obesity and adiposity.
|
25812254 |
2015 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
UCP3-55C/T and the RPTOR-26934C/T may only have subtle effects on the development of obesity-related traits in the present humans.
|
25533680 |
2014 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.
|
24752406 |
2014 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
But neither the UCP2 Ala55Val nor the UCP3 -55C/T polymorphism showed any significant association with obesity risk in either subjects of Asian (REM OR = 0.84, 95% CI: 0.67-1.06 for Ala55Val; REM OR = 0.94, 95% CI: 0.55-1.28 for -55C/T) or of European descent (REM OR = 1.04, 95% CI: 0.80-1.36 for Ala55Val; FEM OR = 1.08, 95% CI: 0.97-1.20 for -55C/T).
|
23560041 |
2013 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We identified four novel mutations in the UCP3 gene (V56M, A111V, V192I and Q252X) in 200 children with severe, early-onset obesity (body mass index-standard deviation score >2.5; onset: <4 years) living in Southern Italy.
|
21544083 |
2012 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the influence of -55CT polymorphism of the UCP3 gene on insulin concentrations and metabolic parameters secondary to two hypocaloric diets in obese patients.
|
18825612 |
2009 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans.
|
19413708 |
2009 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine whether there is an association between the UCP2/UCP3 locus and the obesity in the Japanese population when using a single nucleotide polymorphism (SNP)-based and haplotype-based case-control study with gender-specific analysis.
|
18956255 |
2009 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation in the UCP2-UCP3 gene cluster may act as a modifier increasing serum lipid levels and indices of abdominal obesity, and may thereby also contribute to the metabolic aberrations observed in obesity and type 2 diabetes.
|
19769793 |
2009 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population.
|
18249216 |
2008 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in ADRB1 and UCP3 may contribute to insulin resistance rather than obesity among Swedish women.
|
18059082 |
2008 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Underfeeding for 6 days has no significant effect on UCP3 mRNA expression in skeletal muscle in non-obese men but is associated with changes in carbohydrate fuel partitioning, REE and the thermogenic response to the glucose clamp.
|
17697059 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The V-A-T haplotype within UCP2-UCP3 gene cluster is also significantly associated with obesity in Paiwan aborigines.
|
17502873 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents.
|
17870627 |
2007 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects.
|
16631432 |
2006 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, using the quantitative transmission disequilibrium test (QTDT), we assessed linkage and association between the UCP3 gene and obesity phenotypes in a large sample of 1,873 subjects from 405 United States Caucasian nuclear families.
|
15870396 |
2005 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the LEP and UCP2/UCP3 genes are unlikely to have a substantial effect on variation in obesity phenotypes in this particular US Caucasian population.
|
15910756 |
2005 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
The mitochondrial uncoupling proteins (UCP-2 and UCP-3), which have been suggested to be involved in the development of obesity by controlling the energy expenditure (EE), were studied in 22 healthy first-degree relatives (FDRs) of patients with type 2 diabetes and 13 body mass index (BMI)- and age-matched healthy control subjects.
|
15642081 |
2005 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
UCP3 -55C>T polymorphism carriers have apparently a lower risk of obesity when taking into consideration recreational energy expenditure.
|
16006788 |
2005 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, central obesity in whites as reflected by an increased waist-to-hip ratio is associated with the UCP-1 Ala64Thr and UCP-3 C-55T polymorphisms.
|
12756473 |
2003 |