Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations in uromodulin are responsible for autosomal-dominant kidney diseases characterized by defective urine concentrating ability, hyperuricemia, gout, tubulointerstitial fibrosis, renal cysts, and chronic kidney disease.
|
22237754 |
2012 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We aimed to establish the prevalence of genetic kidney diseases, ADTKD and ADTKD-UMOD in adult chronic kidney disease (CKD) patients, and to investigate characteristic features.
|
30376835 |
2018 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 year of blood pressure intervention, incident CKD case participants in the intensive group had significantly greater decreases in albumin-creatinine ratio (ACR), interleukin-18, anti-chitinase-3-like protein 1 (YKL-40), and uromodulin than the matched control participants.
|
30357395 |
2018 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The genetic rs12917707-G>T variant in uromodulin (UMOD) has been associated with renal function, chronic kidney disease and hypertension with the minor T-allele showing a protective effect.
|
28418009 |
2018 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, elevated uromodulin concentrations precede the onset of CKD and associate with a common polymorphism in the UMOD region.
|
19959715 |
2010 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, genome-wide association studies identified uromodulin as a risk factor for chronic kidney disease (CKD) and hypertension, and suggested that the level of uromodulin in the urine could represent a useful biomarker for the development of CKD.
|
21654721 |
2011 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
UMOD was also associated with a lower rate of transition to stage 3B chronic kidney disease (hazard ratio = 0.83[0.70, 0.99], P = 0.03).
|
23586973 |
2013 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Using a sample of 2377 persons with CKD at the baseline Systolic Blood Pressure Intervention Trial (SPRINT) visit, we evaluated the association of three urine tubular function markers, alpha-1 microglobulin (α1m), beta-2 microglobulin (β2m), and uromodulin, with a composite CVD endpoint (myocardial infarction, acute coronary syndrome, stroke, acute decompensated heart failure, or death from cardiovascular causes) and mortality using Cox proportional hazards regression, adjusted for baseline estimated glomerular filtration rate (eGFR), albuminuria, and CVD risk factors.
|
31257404 |
2019 |
Chronic Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Plasma and 24-h urinary zinc levels, urinary electrolytes and uromodulin were measured in 108 CKD patients and 81 individuals without CKD.
|
31006015 |
2019 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, genome-wide association studies have identified common variants in UMOD that are strongly associated with risk of CKD and also with hypertension and kidney stones in the general population.
|
28781372 |
2017 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, common single nucleotide polymorphisms in the UMOD promoter have been associated with the risk for impaired renal function and chronic kidney disease.
|
26040415 |
2015 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We report mutation analysis of the REN gene in 39 kindreds with hyperuricemia and CKD who previously tested negative for mutations in the UMOD (uromodulin) and HNF1B (hepatocyte nuclear factor 1β) genes.
|
21903317 |
2011 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The results of recent studies suggest an association between CKD development and genetic variation within the uromodulin gene (UMOD).
|
28954491 |
2017 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Individuals (n = 485) were selected based on presence of the GWAS risk haplotype and chronic kidney disease (CKD) in the ARIC Study and on the extremes of of the UMOD gene product, uromodulin, in urine (Tamm Horsfall protein, THP) in the Framingham Heart Study (FHS).
|
22693617 |
2012 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, in the long course of chronic kidney diseases (CKD), SHP sometimes transforms into a hypercalcemic condition resembling the autonomous form of hyperparathyroidism (tertiary hyperparathyroidism; THP).
|
30641516 |
2019 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This study implicates that UMOD might play a role in the relationship between gout and CKD.
|
21332338 |
2011 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Serum uromodulin concentration was inversely associated with the development of CKD, even after adjustment for patients age, sex, genotype of the identified polymorphism, hypertension and diabetes status, and eGFR (odds ratio = 0.263, P = 0.019), and it significantly increased the performance of a prediction model for CKD (C-statistics 0.844 vs. 0.804, P = 0.049).
|
28858977 |
2018 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We measured serum uromodulin concentrations by ELISA in 2652 CKD patients from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) and investigated the association of serum uromodulin with outcomes of CKD patients, including end-stage kidney disease (ESKD) receiving kidney replacement therapy, cardiovascular events and mortality by Cox proportional hazards regression model.
|
30454063 |
2018 |
Chronic Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our findings link genetic susceptibility to hypertension and CKD to the level of uromodulin expression and uromodulin's effect on salt reabsorption in the kidney.
|
24185693 |
2013 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney disease (CKD).
|
21738052 |
2011 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
It provides new information regarding UMOD gene polymorphisms and their association with chronic kidney disease.
|
21071970 |
2011 |
Chronic Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Indeed, mutations in THP cause a group of inherited kidney diseases, and altered THP expression is associated with increased risks of urinary tract infection, kidney stone, hypertension, hyperuricemia and acute and chronic kidney diseases.
|
30649494 |
2020 |
Chronic Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations in the uromodulin (UMOD) gene that encodes Tamm-Horsfall protein (THP) cause an autosomal-dominant form of chronic renal failure.
|
15327389 |
2004 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This review presents some new possible biomarkers in the diagnosis of CKD and in the prediction of outcome, including asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), uromodulin, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), miRNA, ncRNA, and lincRNA biomarkers and proteomic and metabolomic biomarkers.
|
28777303 |
2017 |
Chronic Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This study within persons with known coronary artery disease (CAD) evaluated whether uromodulin concentrations could distinguish CKD risk.
|
21235779 |
2011 |