|
2,8-Dihydroxyadenine Urolithiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In our center, more than 30% (278/911) of kidney transplant (KTx) recipients were diagnosed with a causal nephropathy: Prevalence of rare genetic disorders in this group was 4.32% (12/278), including 2,8-dihydroxyadeninuria (2,8-DHA) disease (n = 2), HNF-1B-associated nephropathy (n = 2), UMOD-related nephropathy (n = 5), Fabry disease (n = 1), INF2 focal segmental glomerulosclerosis (n = 1), and Senior-Løken syndrome (n = 1).
|
24961278 |
2014 |
|
Abnormality of the urinary system
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT).
|
18846391 |
2009 |
|
Acute Coronary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a sample of 2377 persons with CKD at the baseline Systolic Blood Pressure Intervention Trial (SPRINT) visit, we evaluated the association of three urine tubular function markers, alpha-1 microglobulin (α1m), beta-2 microglobulin (β2m), and uromodulin, with a composite CVD endpoint (myocardial infarction, acute coronary syndrome, stroke, acute decompensated heart failure, or death from cardiovascular causes) and mortality using Cox proportional hazards regression, adjusted for baseline estimated glomerular filtration rate (eGFR), albuminuria, and CVD risk factors.
|
31257404 |
2019 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that L-THP, being an isoquinoline alkaloid, could be a potential molecule against acute lymphoblastic leukemia (ALL), in this study, we evaluate L-THP against p53 deficient leukemia EU-4 cell lines in vitro.
|
28721806 |
2017 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum Uromodulin Levels in Prediction of Acute Kidney Injury in the Early Phase of Acute Pancreatitis.
|
28613246 |
2017 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that L-THP, being an isoquinoline alkaloid, could be a potential molecule against acute lymphoblastic leukemia (ALL), in this study, we evaluate L-THP against p53 deficient leukemia EU-4 cell lines in vitro.
|
28721806 |
2017 |
|
Alcohol Use Disorder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we used immunohistochemistry (IHC) to examine 3α,5α-THP levels in the ventral tegmental area (VTA), substantia nigra pars medialis (SNM), and amygdala of human postmortem brains of patients diagnosed with AUD compared with social drinkers.
|
28068457 |
2017 |
|
Alcohol Use Disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
For many years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone or 3α,5α-THP) may have therapeutic potential for treatment of various symptoms of alcohol use disorders (AUDs).
|
31782169 |
2020 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The endogenous neurosteroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP, allopregnanolone) has protective activity in animal models of alcoholism, depression, traumatic brain injury, schizophrenia, multiple sclerosis, and Alzheimer's disease that is poorly understood.
|
30718548 |
2019 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Influence of Acetylcholinesterase Inhibitors Used in Alzheimer's Disease Treatment on the Activity of Antioxidant Enzymes and the Concentration of Glutathione in <i>THP-1</i> Macrophages under Fluoride-Induced Oxidative Stress.
|
30577562 |
2018 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The endogenous neurosteroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP, allopregnanolone) has protective activity in animal models of alcoholism, depression, traumatic brain injury, schizophrenia, multiple sclerosis, and Alzheimer's disease that is poorly understood.
|
30718548 |
2019 |
|
Anorexia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with malignant lymphoma who received CHOP chemotherapy or THP (THP-ADR)-COP therapy were investigated for CINV and anorexia for 5 days after the start of chemotherapy.
|
29061362 |
2018 |
|
Anxiety
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we show that THP (allopregnanolone), a steroid that is released as a result of stress, increases anxiety in pubertal female mice, in contrast to its anxiety-reducing effect in adults.
|
17351635 |
2007 |
|
Anxiety
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The hypothesis was that if some of the estrous cycle differences in exploratory (open field) and anxiety (elevated plus maze) are due to P's 5α-reduction to 5α-pregnan-3α-ol-20-one (3α,5α-THP), then wildtype mice will have estrous cycle differences in the expression of these behaviors, but 5αRKO mice will not.
|
21946309 |
2012 |
|
Anxiety Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Here we show that THP (allopregnanolone), a steroid that is released as a result of stress, increases anxiety in pubertal female mice, in contrast to its anxiety-reducing effect in adults.
|
17351635 |
2007 |
|
Anxiety Disorders
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The hypothesis was that if some of the estrous cycle differences in exploratory (open field) and anxiety (elevated plus maze) are due to P's 5α-reduction to 5α-pregnan-3α-ol-20-one (3α,5α-THP), then wildtype mice will have estrous cycle differences in the expression of these behaviors, but 5αRKO mice will not.
|
21946309 |
2012 |
|
Aortic Aneurysm
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present research, we evaluated the effects of L-THP on the progression of aortic aneurysms (AAs) in experimental rats induced with perfusion of elastase.
|
29388563 |
2018 |
|
Aortic Stiffness
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.
|
31003921 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As a replication set, we tested the genotype association with uromodulin concentration in the Atherosclerosis Risk in Communities (ARIC) Study (n = 42).
|
19959715 |
2010 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As a replication set, we tested the genotype association with uromodulin concentration in the Atherosclerosis Risk in Communities (ARIC) Study (n = 42).
|
19959715 |
2010 |
|
Autoimmune Chronic Hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study indicated that L-THP attenuated acute liver injury in ConA-induced autoimmune hepatitis by inhibiting apoptosis and autophagy via the TRAF6/JNK pathway.
|
30622431 |
2018 |
|
Autoimmune hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study indicated that L-THP attenuated acute liver injury in ConA-induced autoimmune hepatitis by inhibiting apoptosis and autophagy via the TRAF6/JNK pathway.
|
30622431 |
2018 |
|
Autosomal dominant tubulointerstitial kidney disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autosomal dominant medullary cystic kidney disease type 2 (MCKD2) is a tubulo-in terstitial nephropathy that causes renal salt wasting, hyperuricemia, gout, and end-stage renal failure in the fifth decade of life.
|
17245395 |
2007 |
|
Autosomal dominant tubulointerstitial kidney disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a 3-year-old Chinese boy in an ADTKD family caused by a novel UMOD gene mutation.
|
31068150 |
2019 |
|
Autosomal dominant tubulointerstitial kidney disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Uromodulin kidney disease (UKD) is a subtype of autosomal dominant tubulointerstitial kidney disease (ADTKD), and is a rare cause of renal failure and gout in young people.
|
31157132 |
2019 |