UMOD, uromodulin, 7369

N. diseases: 164; N. variants: 35
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.160 GeneticVariation disease BEFREE The present study highlights that the common variant of the UMOD gene is protective against diabetic nephropathy susceptibility and also affects kidney function and blood pressure in patients with type 2 diabetes. 21738052 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.160 Biomarker disease BEFREE Prospectively, uromodulin was lowest in patients with T2DM at baseline, higher in initially nondiabetic subjects who developed diabetes during follow-up (FU) and highest among nondiabetic patients (147.7 ± 69.9 vs 164 ± 67 vs 179.9 ± 82.2 ng/mL, Ptrend < 0.001). 28151855 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.160 GeneticVariation disease BEFREE In this study, we investigated the association between rs4293393 variation in UMOD gene and susceptibility to kidney disease in individuals with type 2 diabetes mellitus (T2DM). 29578190 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.160 GeneticVariation disease BEFREE The rs12917707 polymorphism at the UMOD locus and glomerular filtration rate in individuals with type 2 diabetes: evidence of heterogeneity across two different European populations. 27448670 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.160 GeneticVariation disease GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.160 AlteredExpression disease BEFREE Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus. 29779026 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.160 Biomarker disease BEFREE In participants of the KORA F4 study, serum uromodulin is independently associated with T2D in men, but is no predictor of future development of T2D. 30892596 2019