UMOD, uromodulin, 7369

N. diseases: 164; N. variants: 35
Disease: Anxiety Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.020 GeneticVariation group BEFREE The hypothesis was that if some of the estrous cycle differences in exploratory (open field) and anxiety (elevated plus maze) are due to P's 5α-reduction to 5α-pregnan-3α-ol-20-one (3α,5α-THP), then wildtype mice will have estrous cycle differences in the expression of these behaviors, but 5αRKO mice will not. 21946309 2012
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.020 Biomarker group BEFREE Here we show that THP (allopregnanolone), a steroid that is released as a result of stress, increases anxiety in pubertal female mice, in contrast to its anxiety-reducing effect in adults. 17351635 2007