UMOD, uromodulin, 7369

N. diseases: 164; N. variants: 35
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 Biomarker disease BEFREE Additionally, uromodulin is independently associated with AKI development after adjusting for clinically relevant parameters such as age, sex, diabetes, hypertension, severity of cirrhosis, and kidney function. 31411505 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease BEFREE Serum uromodulin concentration was inversely associated with the development of CKD, even after adjustment for patients age, sex, genotype of the identified polymorphism, hypertension and diabetes status, and eGFR (odds ratio = 0.263, P = 0.019), and it significantly increased the performance of a prediction model for CKD (C-statistics 0.844 vs. 0.804, P = 0.049). 28858977 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 Biomarker disease BEFREE Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control. 30158836 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 Biomarker disease BEFREE Prospectively, uromodulin was lowest in patients with T2DM at baseline, higher in initially nondiabetic subjects who developed diabetes during follow-up (FU) and highest among nondiabetic patients (147.7 ± 69.9 vs 164 ± 67 vs 179.9 ± 82.2 ng/mL, Ptrend < 0.001). 28151855 2017
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 Biomarker disease BEFREE Serum uromodulin proved protective for overall mortality (HR=0.56 [95%CI 0.43-0.72]; p<0.001), even after full adjustment including eGFR, current smoking, diabetes, and CAD status (adj.HR=0.57 [95%CI 0.37-0.89]; p=0.014). 28089453 2017
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 Biomarker disease BEFREE We conclude that UMOD is unlikely to play a role in IgA nephropathy pathogenesis nor progression to end stage renal failure, and suggest that UMOD effects are restricted to some causes of renal disease, e.g. diabetes or hypertension. 25163389 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 Biomarker disease BEFREE Previous studies have identified an association between low level of urinary uromodulin (UMOD) and CKD within the setting of diabetes and lupus. 21332338 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.180 GeneticVariation disease BEFREE These results suggest that the UMOD variant may influence the adaptation of the kidney to age-related risk factors of kidney disease such as hypertension and diabetes. 20686651 2010