|
Cytogenetically normal acute myeloid leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
KDM6A expression is heterogeneously regulated and relapse-specific loss of KDM6A was observed in 45.7% of CN-AML patients.
|
31201358 |
2020 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Consistent with an increased transcriptional response to hypoxia in pancreatic adenocarcinomas bearing KDM6A inactivation, we showed that mutation or reduced KDM6A expression in SPNs is associated with increased expression of the HIF1α-regulated protein GLUT1 at both primary and metastatic sites.
|
30306561 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of UTX in the thymus of RA mice were significantly reduced.
|
31297569 |
2019 |
|
Chondrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the antitumoral potential of GSK-J4, a small molecule described as an inhibitor of histone demethylases UTX and JMJD3 (KDM6A and KDM6B), alone or in combination with cisplatin in CSs.
|
31241814 |
2019 |
|
Klinefelter Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
KDM6A, important for germ cell development, has shown to be differentially expressed and methylated in Turner and Klinefelter syndrome across studies.
|
30811826 |
2019 |
|
Leukemia, T-Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Deleterious mutations in KDM6A are found in many cancer types, prominently urothelial carcinoma and certain T-cell leukemias.
|
30628063 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Synergistic triad epistasis of epigenetic H3K27me modifier genes, EZH2, KDM6A, and KDM6B, in gastric cancer susceptibility.
|
30374835 |
2019 |
|
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study concisely shows the value of X chromosome gene expression in T cell regulation of autoimmunity and the relevance of Kdm6a in the pathogenesis of EAE as a model of MS.
|
31403466 |
2019 |
|
Neural Tube Defects
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We also report that p53S decreased expression of UTX at mRNA and protein level via increasing Xist transcript, result in high female-specific H3K27me3 expression and repressed Mash1 transcription, which facilitating abnormal proliferation, differentiation, and apoptosis, result in the mis-regulation of neurodevelopment and neural tube defects (NTDs).
|
31523200 |
2019 |
|
Kaposi Sarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study describes 5 novel variants of 7 KMT2D/KDM6A gene and summarizes the clinical manifestations and the mutational spectrum of 47 Chinese Kabuki syndrome (KS) patients.
|
31727177 |
2019 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
This finding provides a basis for further study of Kdm6a as a new regulator for AMI development.
|
30887465 |
2019 |
|
Klinefelter's syndrome - male with more than two X chromosomes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
KDM6A, important for germ cell development, has shown to be differentially expressed and methylated in Turner and Klinefelter syndrome across studies.
|
30811826 |
2019 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Synergistic triad epistasis of epigenetic H3K27me modifier genes, EZH2, KDM6A, and KDM6B, in gastric cancer susceptibility.
|
30374835 |
2019 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although genomic analysis have recently discovered the malignant subtype of human pancreatic ductal adenocarcinoma (PDAC) characterized by frequent mutations of histone demethylase KDM6A, the biological and molecular roles still remain obscure.
|
30556125 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, KDM6A exhibited essential roles in human PDAC as a tumor suppressor and KDM6A deficiency could be a promising biomarker for unfavorable outcome in PDAC patients and a potential surrogate marker for response to HDAC inhibitors.
|
30556125 |
2019 |
|
Insulin-Like Growth Factor I Deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The pathophysiology of the sensorineural hearing loss in TS is not known, but theories regarding estrogen deficiency, the cell cycle delay hypothesis, IGF-1 deficiency and the possible role of the KDM6A gene are discussed.
|
30632288 |
2019 |
|
Urothelial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data indicate that UTX does not act in a uniform fashion in UC.
|
30987376 |
2019 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conversely, inhibition of the Jumonji C domain-containing demethylases Jmjd3 and UTX increased the H3K27me3 content of podocytes and attenuated glomerular disease in adriamycin nephrotoxicity, SNx, and diabetes.
|
29227285 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Conversely, inhibition of the Jumonji C domain-containing demethylases Jmjd3 and UTX increased the H3K27me3 content of podocytes and attenuated glomerular disease in adriamycin nephrotoxicity, SNx, and diabetes.
|
29227285 |
2018 |
|
Focal glomerulosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Podocytes in glomeruli from humans with focal segmental glomerulosclerosis or diabetic nephropathy exhibited diminished H3K27me3 and heightened UTX content.
|
29227285 |
2018 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease.
|
29281014 |
2018 |
|
Congenital Hydrocephalus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we described a male patient with a novel KDM6A splicing in exon(exon4) and flanking intron(intron3)-exon boundaries characterized by congenital hydrocephalus which had never been reported before.
|
30509212 |
2018 |
|
Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Insulin secretion was studied in pancreatic islets and in mouse islets treated with an inhibitor of KDM6A, an X chromosome gene associated with hyperinsulinism in Kabuki syndrome.
|
29902804 |
2018 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Analogous to human disease, inhibition of Jmjd3 and UTX abated nephropathy progression in mice with established glomerular injury and reduced H3K27me3 levels.
|
29227285 |
2018 |
|
melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also identified two genes significantly associated with melanoma metastasis to the regional lymph nodes (PIK3CG and IL2RA), and two genes significantly associated with sex (KDM5C and KDM6A).
|
29975213 |
2018 |