KDM6A, lysine demethylase 6A, 7403

N. diseases: 238; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.320 GeneticVariation disease BEFREE Rebalance of H3K27me3 levels at specific genes through EZH2 inhibitors may be a therapeutic strategy in MM cases harboring UTX mutations. 29045832 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.320 GeneticVariation disease BEFREE Myeloma is linked to the overexpression of a histone methylatransferase (MMSET) and inactivating mutations of a histone demethylase (UTX), suggesting that the regulation of histone methylation is a potential therapeutic target. 19912222 2010
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.320 CausalMutation disease CGI
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.320 GenomicAlterations disease CGI