Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of the head and neck
0.100 Biomarker disease BEFREE Thus, ACTL6A and p63 collaborate as oncogenic drivers in HNSCC. 28041841 2017
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE Importantly, p63 expression is positively correlated with CD44, HAS3, and ABCC1 expression in squamous cell carcinoma datasets and p63-HA pathway is a negative prognostic factor of HNSCC patient survival. 29162693 2017
Squamous cell carcinoma of the head and neck
0.100 Biomarker disease BEFREE In this report, CK19 and p63 were immunohistochemically examined in primary tumours for use as molecular markers and were compared with cytokeratin 903 (CK903), cytokeratin 8/18 (CK8/18) and cytokeratin (AE1/AE3), which are used in diagnostic immunohistochemistry for head and neck squamous cell carcinoma. 21705376 2011
Squamous cell carcinoma of the head and neck
0.100 Biomarker disease BEFREE ΔNp63α, the dominant negative isoform of the p63 family is an essential survival factor in head and neck squamous cell carcinoma. 21088498 2010
Squamous cell carcinoma of the head and neck
0.100 Biomarker disease BEFREE The p53 homologue p63 produces six different isoforms that are important in development of epithelial tissues and squamous cell carcinoma of the head and neck (SCCHN). 19391123 2009
Squamous cell carcinoma of the head and neck
0.100 Biomarker disease BEFREE It has also been suggested that p63 is involved in development of squamous cell carcinoma of the head and neck (SCCHN). 17418619 2008
Squamous cell carcinoma of the head and neck
0.100 Biomarker disease BEFREE DeltaNp63alpha, the dominant negative isoform of the p63 family is an essential survival factor in head and neck squamous cell carcinoma. 18418053 2008
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE The human p63 gene codes for multiple protein isoforms and is commonly over-expressed in squamous cell carcinoma of head and neck (SCCHN). 17935121 2007
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE Disrupting endogenous p63 expression resulted in downregulation of TRAF4 mRNA and protein in an SCCHN cell line. 18087216 2007
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE Biopsies from patients diagnosed with OLP and GVHD were analysed for p63 protein expression using antibodies distinguishing between the major isoforms expressed in normal epithelia, in parallel with biopsies from normal buccal mucosa and SCCHN. 16393253 2006
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE Immunoblotting was used to examine the effects of Gleevec on p63 protein levels in HNSCC cell lines in response to DNA damage. 16885742 2006
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE Various changes have been described at different stages of SCCHN tumour development, including overexpression of p63, a protein important for development of normal epidermal structures. p63 has been suggested to activate beta-catenin, and nuclear accumulation of beta-catenin is an important event in many cancers. 16273222 2005
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE In experiment 1, analysis of 36 HNSCC specimens from various head and neck subsites showed p63 expression in all tumors and matched normal tissue specimens (36 of 36). 15564824 2004
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE Complex p63 mRNA isoform expression patterns in squamous cell carcinoma of the head and neck. 15201986 2004
Squamous cell carcinoma of the head and neck
0.100 AlteredExpression disease BEFREE The objective was to investigate whether p63 expression is decreased after treatment of HNSCC cells with ZD1839. 12782800 2003