Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
We concluded that Vav2 might promote invasion and metastasis of gastric cancer by regulating some invasion and metastasis-related genes.
|
28459214 |
2017 |
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Expression of constitutively active Vav2 and RhoA in cells depleted for RIAM partially rescued their invasion, indicating that Vav2 and RhoA mediate RIAM function.
|
21454517 |
2011 |
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Given the regulatory role of Vav2, the function of Nek3 in PRL-mediated motility and invasion was examined.
|
17297458 |
2007 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Finally, we confirmed that a dual targeting strategy is a viable and efficient therapeutic approach to hinder the metastasis of breast cancer in xenograft models, showcasing the important need for further clinical evaluation of this regimen to impede the spread of disease and improve patient survival.<b>Implications:</b> This study provides new insight into the therapeutic benefit of combining NEDD9 depletion with ROCK inhibition to reduce tumor cell dissemination and discovers a new regulatory role of NEDD9 in the modulation of VAV2-dependent activation of Rac1 and actin polymerization.<i></i>.
|
28235899 |
2017 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
We concluded that Vav2 might promote invasion and metastasis of gastric cancer by regulating some invasion and metastasis-related genes.
|
28459214 |
2017 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Altogether, our work suggested that EphB3 acted as a tumor promoter in PTC by increasing the in vitro migration as well as the in vivo metastasis of PTC cells through regulating the activities of Vav2 and Rho GTPases in a kinase-dependent manner.
|
27986811 |
2017 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Altogether, our work suggested that EphB3 acted as a tumor promoter in PTC by increasing the in vitro migration as well as the in vivo metastasis of PTC cells through regulating the activities of Vav2 and Rho GTPases in a kinase-dependent manner.
|
27986811 |
2017 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Finally, we confirmed that a dual targeting strategy is a viable and efficient therapeutic approach to hinder the metastasis of breast cancer in xenograft models, showcasing the important need for further clinical evaluation of this regimen to impede the spread of disease and improve patient survival.<b>Implications:</b> This study provides new insight into the therapeutic benefit of combining NEDD9 depletion with ROCK inhibition to reduce tumor cell dissemination and discovers a new regulatory role of NEDD9 in the modulation of VAV2-dependent activation of Rac1 and actin polymerization.<i></i>.
|
28235899 |
2017 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Expression of Vav2 protein in gastric cancer tissues was related to degree of tumor differentiation, lymph node metastasis, and clinical stages.
|
28459214 |
2017 |
Agenesis of corpus callosum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Because VAV2 is a druggable target, our findings suggest that blocking VAV2 may be a new therapeutic approach to inhibit metastatic progression in ACC patients.
|
28270555 |
2017 |
Agenesis of corpus callosum
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To assess the prognostic role of VAV2 expression in ACC by investigation of a large cohort of patients.
|
28911143 |
2017 |
Aplasia Cutis Congenita
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To assess the prognostic role of VAV2 expression in ACC by investigation of a large cohort of patients.
|
28911143 |
2017 |
Aplasia Cutis Congenita
|
0.020 |
Biomarker
|
disease |
BEFREE |
Because VAV2 is a druggable target, our findings suggest that blocking VAV2 may be a new therapeutic approach to inhibit metastatic progression in ACC patients.
|
28270555 |
2017 |
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic disruption of Vav2 in ApoE-deficient C57BL/6 mice significantly inhibited the severity of atherosclerosis.
|
31570505 |
2019 |
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic disruption of Vav2 in ApoE-deficient C57BL/6 mice significantly inhibited the severity of atherosclerosis.
|
31570505 |
2019 |
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MicroRNA-331-3p inhibits epithelial-mesenchymal transition by targeting ErbB2 and VAV2 through the Rac1/PAK1/β-catenin axis in non-small-cell lung cancer.
|
30955235 |
2019 |
Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In diabetes, Rac1 prenylation and its interactions with Vav2 contribute to Nox2-ROS-mitochondrial damage, and the pharmacological inhibitors to attenuate Rac1 interactions with its regulators could have the potential to halt/inhibit the development of diabetic retinopathy.
|
31300985 |
2019 |
Total anomalous pulmonary venous return
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, SNAI1, HMGA2 and VAV2 are novel TAPVC candidate genes that have not been reported previously in either humans or animals.
|
30448225 |
2018 |
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
We concluded that Vav2 might promote invasion and metastasis of gastric cancer by regulating some invasion and metastasis-related genes.
|
28459214 |
2017 |
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results show that being carrier of the T allele in VAV2 rs602990 polymorphism is associated with an increased risk of obesity, reduced levels of ankle-brachial index and diastolic blood pressure and reduced retinal artery caliber.
|
28157227 |
2017 |
Glomerulosclerosis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Local transfection of Vav2 shRNA plasmids significantly attenuated hHcys-induced NLRP3 inflammasome activation, podocyte injury, and glomerular sclerosis.
|
28193546 |
2017 |
Adrenocortical carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma.
|
28911143 |
2017 |
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, our work suggested that EphB3 acted as a tumor promoter in PTC by increasing the in vitro migration as well as the in vivo metastasis of PTC cells through regulating the activities of Vav2 and Rho GTPases in a kinase-dependent manner.
|
27986811 |
2017 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Several studies have proved that Vav2 gene is associated with the carcinogenesis of some tumors, but the relationship between Vav2 gene and gastric cancer remains unclear.
|
28459214 |
2017 |
Hyperhomocysteinemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a mouse model of hyperhomocysteinemia (hHcys), we found that mice with hHcys (on the FF diet) or oncoVav2 (a constitutively active form of Vav2) transfection in the kidney exhibited increased colocalization of NLRP3 with apoptosis-associated speck-like protein (ASC) or caspase-1 and elevated IL-1β levels in glomeruli, indicating the formation and activation of the NLRP3 inflammasome.
|
28193546 |
2017 |