|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, vinculin could be used as a prognostic marker for NSCLC and a potential target for its treatment.
|
30947597 |
2020 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pearson correlation analysis showed that vinculin expression was significantly correlated with tumor-node-metastasis (TNM) stage and lymph node metastasis in NSCLC.
|
30947597 |
2020 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, global transcriptional profiling revealed that adhesion and cytoskeletal proteins such as Vinculin, Talin and signaling pathways including focal adhesion kinase (FAK), extracellular martrix (ECM) receptor interaction, and cellular motility were significantly enriched in U87 and T98 glioblastoma cells upon LKB1 knockdown.
|
31497348 |
2019 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that depletion of Huntingtin in human fibroblasts reduced adhesion and altered morphology and these phenotypes were made worse with growth factor stimulation, whereas the presence of the Huntington's Disease mutation inhibited growth factor induced changes in morphology and increased numbers of vinculin-positive focal adhesions.
|
30768638 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Performing epitope stabilization for CdtB and vinculin enhances the test characteristics of ELISAs for anti-CdtB and anti-vinculin in discriminating IBS-D from IBD.
|
31152332 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we assessed the expression of vinculin in GC cell lines.
|
30989694 |
2019 |
|
Rhabdoid Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
In differential diagnosis, other tumors, such as malignant rhabdoid tumor (MRT), vinculin-anaplastic lymphoma kinase (VCL-ALK) translocation renal cell carcinoma, and collecting duct carcinoma, may present difficulties.
|
30656488 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, global transcriptional profiling revealed that adhesion and cytoskeletal proteins such as Vinculin, Talin and signaling pathways including focal adhesion kinase (FAK), extracellular martrix (ECM) receptor interaction, and cellular motility were significantly enriched in U87 and T98 glioblastoma cells upon LKB1 knockdown.
|
31497348 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
By bioinformatics analysis, the four up-regulated proteins (PTMA, PAK2, PPP1CA, HMGB2) and the five down-regulated proteins (Caveolin, Integrin beta-1, Collagen alpha-2(VI), Leiomodin-1 and Vinculin) were selected and validated in ESCC by Western Blot.
|
30988666 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, global transcriptional profiling revealed that adhesion and cytoskeletal proteins such as Vinculin, Talin and signaling pathways including focal adhesion kinase (FAK), extracellular martrix (ECM) receptor interaction, and cellular motility were significantly enriched in U87 and T98 glioblastoma cells upon LKB1 knockdown.
|
31497348 |
2019 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we assessed the expression of vinculin in GC cell lines.
|
30989694 |
2019 |
|
Collecting Duct Carcinoma of the Kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
In differential diagnosis, other tumors, such as malignant rhabdoid tumor (MRT), vinculin-anaplastic lymphoma kinase (VCL-ALK) translocation renal cell carcinoma, and collecting duct carcinoma, may present difficulties.
|
30656488 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, global transcriptional profiling revealed that adhesion and cytoskeletal proteins such as Vinculin, Talin and signaling pathways including focal adhesion kinase (FAK), extracellular martrix (ECM) receptor interaction, and cellular motility were significantly enriched in U87 and T98 glioblastoma cells upon LKB1 knockdown.
|
31497348 |
2019 |
|
Refractory Cytopenia of Childhood
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeted next-generation sequencing revealed distinct clinicopathologic and molecular features of VCL-ALK RCC: A unique case from an older patient without clinical evidence of sickle cell trait.
|
31563285 |
2019 |
|
MiT family translocation renal cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In differential diagnosis, other tumors, such as malignant rhabdoid tumor (MRT), vinculin-anaplastic lymphoma kinase (VCL-ALK) translocation renal cell carcinoma, and collecting duct carcinoma, may present difficulties.
|
30656488 |
2019 |
|
Membranous glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In kidney sections from patients with focal segmental glomerulosclerosis, minimal change disease and membranous nephropathy, we observed dramatic differences in the expression levels and localization of vinculin.
|
29241625 |
2018 |
|
Cutaneous Fibrous Histiocytoma, Epithelioid Variant
|
0.010 |
Biomarker
|
disease |
BEFREE |
SQSTM1 and VCL have previously been shown to partner with ALK in one case each of epithelioid fibrous histiocytoma.
|
29327718 |
2018 |
|
Secondary Neoplasm
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
Here we show that in human invasive carcinomas and distant metastases, cytoplasmic EZH2 phosphorylated at T367 is significantly associated with ER- disease and low H3K27me3 levels. p38-mediated EZH2 phosphorylation at T367 promotes EZH2 cytoplasmic localization and potentiates EZH2 binding to vinculin and other cytoskeletal regulators of cell migration and invasion.
|
30022044 |
2018 |
|
Acidosis, Respiratory
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study initially shows both physical and functional interaction between VCL and cardiac sodium channel, and suggests an important role for respiratory acidosis in triggering the fatal arrhythmia underlying SUNDS.
|
28218286 |
2017 |
|
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study initially shows both physical and functional interaction between VCL and cardiac sodium channel, and suggests an important role for respiratory acidosis in triggering the fatal arrhythmia underlying SUNDS.
|
28218286 |
2017 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, ACTN1 and VCL may play roles in bladder cancer development, partly via the focal adhesion pathway.
|
28552713 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we find that ERα is a novel regulator of vinculin expression in breast cancer.
|
28266545 |
2017 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In non-inflamed UC (QUC) keratins, vimentin, and focal adhesion kinase (7) increased, whereas vinculin and de-tyrosinated α-tubulin decreased; inflammation (IUC) exacerbated molecular changes, being collagen type VI alpha 1 chain (COL6A1), tenascin-C and vimentin increased.
|
29027377 |
2017 |
|
Diarrhea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Antibodies to cytolethal distending toxin B (CdtB) and vinculin are novel biomarkers that rule-in and differentiate irritable bowel syndrome with diarrhea (IBS-D) from other causes of diarrhea and healthy controls.
|
28451914 |
2017 |
|
Muscle Rigidity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The tension gradient is actomyosin- and vinculin-dependent and sensitive to the rigidity of the extracellular environment.
|
28945706 |
2017 |