Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Based on these results, we performed three different antiangiogenic experiments targeted to inhibit VEGF expression in a human malignant glioma (U87) mouse model: anti-VEGF neutralized antibody intraperitoneal injection; interferon-beta intramusclar injection; and transfection of an endogenous nonspecific angiogenesis inhibitor, thrombospondin-1, into glioma cells caused inhibition of VEGF secretion and/or mRNA expression and resulted in glioma growth inhibition of 70%, 84%, and 50%, respectively, compared with control.
|
15700836 |
2004 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We compared the effect of inhibiting IL6 and VEGF on U87-derived experimental glioma grown on the chick chorio-allantoic membrane (CAM) or in the brain of xenografted mice.
|
19431143 |
2009 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Of various cytokines and growth factors, basic fibroblast growth factor (bFGF), tumor necrosis factor alpha (TNF-alpha), and interleukin 1 most potently enhanced VEGF mRNA levels of a glioma cell line, U251.
|
8910439 |
1996 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The K<sup>trans</sup> derived from DCE-MRI can reflect the VEGF expression of high-grade gliomas but not the MVD.
|
29330968 |
2018 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that CYP4A inhibition by FLA-16 prolongs survival and normalizes vasculature in glioma through decreasing production of TAMs and EPCs-derived VEGF and TGF-β.
|
28602979 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth.
|
22393126 |
2012 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is unknown how VEGF and VEGF receptors are upregulated during glioma angiogenesis, but there is recent evidence that VEGF as well as endogenous inhibitors of angiogenesis could be under control of the tumor suppressor genes p53 and VHL.
|
8586468 |
1995 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We recently showed that VEGF promoter activity is inversely correlated with tumor extracellular pH (pH(o)) in vivo in the human glioma (U87 MG) xenografts.
|
11741977 |
2002 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LRRC4 overexpression inhibited glioma cell invasion through miR-185-mediated CDC42 and RhoA direct regulation and VEGFA indirect regulation.
|
22834685 |
2012 |
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cytokines related to glioma risk (P ≤ .05) more than 10 years before diagnosis are sIL10RB, VEGF, beta-Catenin and CCL22.
|
28594935 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, there was not statistical differences in both VEGF levels and angiogenic capacity in patients with low-grade gliomas and controls.
|
31624989 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nine radiomic features were selected to generate a VEGF-associated radiomic signature of diffuse gliomas based on the mRMR algorithm.
|
31639060 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of VEGF-A as a direct target for miRNA-205 may imply that miRNA-205 is a novel target for glioma therapy.
|
22159356 |
2012 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, [<sup>123</sup>I]-VEGF may provide relevant prognostic information in patients with glioma.
|
30062604 |
2018 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression.
|
30429891 |
2018 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the inhibiting efficacy of AAV2-VEGF-Trap for glioma.
|
30136881 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We now report that AAL881, a novel low-molecular weight inhibitor of the kinase activities associated with B-RAF, C-RAF (RAF-1), and VEGF receptor-2 (VEGFR2), showed activity against glioma cell lines and xenografts.
|
16951188 |
2006 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistently, IRF1 depletion increased the efficacy of anti-VEGF therapy in a glioma xenograft model, which was due to less bevacizumab-promoted autophagy and increased apoptosis in tumors with down-regulated IRF1.
|
26362401 |
2015 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conversely, RNA interference-mediated knockdown of US28 in human glioma cells persistently infected with HCMV led to an inhibition in VEGF expression and glioma cell invasion in response to CCL5 stimulation.
|
21900396 |
2011 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Correlation of Delta-like ligand 4 (DLL4) with VEGF and HIF-1α expression in human glioma.
|
21517260 |
2011 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing of HSP47 decreased VEGF expression in glioma cells consistently, and reduced glioma vasculature.
|
25758142 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms.
|
7525492 |
1994 |
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The VEGF polymorphism rs833061 was strongly associated with increased risk for glioma (odds ratio = 164.85) and glioblastoma (odds ratio = 155.66), confirmed after Bonferroni correction.
|
29584591 |
2018 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glioma stem cells (GSCs) are capable of forming vasculogenic mimicry (VM), an alternative microvascular circulation independent of VEGF-driven angiogenesis.
|
28812437 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential Effects of Ang-2/VEGF-A Inhibiting Antibodies in Combination with Radio- or Chemotherapy in Glioma.
|
30845704 |
2019 |