VEGFA, vascular endothelial growth factor A, 7422

N. diseases: 1899; N. variants: 59
Disease: Adult Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE In situ analysis of tumour specimens undergoing neovascularization show that the production of VEGF is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci (presumably hypoxic regions) and the clustering of capillaries alongside VEGF-producing cells. 1279431 1992
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE A human glioblastoma cell line produced VEGF, which enhanced the proliferation of BCE cells and induced an elongated shape in collagen gels. 8246443 1993
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE These results suggest that VEGF plays a major angiogenic role in glioblastoma. 8710899 1996
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Increases in VEGF mRNA levels were also observed in cultured human melanoma and rat glioblastoma cells with superoxide or hydrogen peroxide. 8833917 1996
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells. 9242380 1997
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF), a potent angiogenic and vascular permeability factor, is important in the angiogenesis of glioblastoma. 9255258 1997
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE Thus, by introducing VEGF-overexpressing glioblastoma cells into the brain, we have established a reproducible and predictable in vivo model of tumor-associated intracerebral hemorrhage caused by the enhanced expression of single molecular species. 9342366 1997
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Studies of glioblastoma angiogenesis have revealed that expression of the vascular endothelial growth factor (VEGF) is up-regulated in these tumors. 9592205 1998
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Following incubation of glioblastoma cell lines under hypoxic/anoxic conditions for 24-48 hours, Fas mRNA levels remained unchanged, whereas VEGF expression was markedly upregulated. 9600216 1998
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Finally, in situ hybridization on glioblastoma sections shows that the in vivo expression patterns of IL-8 and VEGF genes overlap, but are not identical. 10050881 1999
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE Since malignant gliomas frequently show EGF receptor amplification and express IL-1, a pivotal regulatory cytokine involved in angiogenesis, we analyzed interactions between EGF/EGF receptor and IL-1/IL-1 receptor and VEGF in the established glioblastoma cell lines U-87 MG and A-172. 10571418 1999
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Here we report that when protein kinase C (PKC) pathways were activated in human glioblastoma U373 cells by phorbol 12-myristate 13-acetate (PMA), VEGF mRNA expression was up-regulated via a post-transcriptional mRNA stabilization mechanism. 10336429 1999
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE In the present study, the regulatory mechanism of the expression of VEGF by ionizing radiation was studied in three human glioblastoma cells. 10885623 2000
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE We examined VEGF regulation in U87 MG human glioblastoma cells and in U87/T691 cells, a clonal derivative that contains a truncated erbB2/Neu receptor that interferes with EGFR signaling through the formation of nonfunctional heterodimeric receptor complexes. 11059786 2000
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE Coexpression of VEGF and 150-kDa oxygen-regulated protein (ORP), a novel ER chaperone, in human glioblastoma suggested a link between angiogenesis and ORP150. 11358846 2001
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE These results suggest that HDAC inhibitors reduce VEGF secretion and modulate the expression of the other VEGF family members, and therefore may inhibit angiogenesis in glioblastoma tissues. 12622137 2002
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Here we show that substitution of the neutral culture medium (pH 7.3) with acidic pH medium (pH 6.6) up-regulates VEGF mRNA and protein production in human glioblastoma cells as reflected by Northern blot analysis and enzyme-linked immunosorbent assay. 11741977 2002
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. 12517803 2003
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE The potential therapeutic relevance of ZFP-mediated VEGF-A repression was addressed using the highly tumorigenic glioblastoma cell line U87MG. 14695215 2003
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE Based on previous data on an autocrine function of VEGF in Flt-1-expressing glioblastoma cells we hypothesise that the X-ray radiation induced upregulation of VEGF might result in a downregulation of tumour cell proliferation and thus lead to a reduced sensitivity to radiation therapy. 15015778 2004
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE In conclusion, our VAI-embedded anti-VEGF ribozyme is a good inhibitor of angiogenesis in vitro, in a glioblastoma cell context. 15084786 2004
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE In this study a soluble vascular endothelial growth factor receptor (sFlt-1) and an angiostatin-endostatin fusion gene (statin-AE) were codelivered to human glioblastoma xenografts by nonviral gene transfer using the Sleeping Beauty (SB) transposon. 16150649 2005
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE We have scrutinized the mechanism of transcriptional activation of vascular endothelial growth factor (VEGF) expression by IL-6 in the mouse brain and in glioblastoma cells. 15688401 2005
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 AlteredExpression disease BEFREE hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines. 16175187 2005
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.100 Biomarker disease BEFREE VEGF protein was highest in glioblastoma and metastatic kidney tumors. 15949234 2005