Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In situ analysis of tumour specimens undergoing neovascularization show that the production of VEGF is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci (presumably hypoxic regions) and the clustering of capillaries alongside VEGF-producing cells.
|
1279431 |
1992 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A human glioblastoma cell line produced VEGF, which enhanced the proliferation of BCE cells and induced an elongated shape in collagen gels.
|
8246443 |
1993 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that VEGF plays a major angiogenic role in glioblastoma.
|
8710899 |
1996 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increases in VEGF mRNA levels were also observed in cultured human melanoma and rat glioblastoma cells with superoxide or hydrogen peroxide.
|
8833917 |
1996 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells.
|
9242380 |
1997 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF), a potent angiogenic and vascular permeability factor, is important in the angiogenesis of glioblastoma.
|
9255258 |
1997 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, by introducing VEGF-overexpressing glioblastoma cells into the brain, we have established a reproducible and predictable in vivo model of tumor-associated intracerebral hemorrhage caused by the enhanced expression of single molecular species.
|
9342366 |
1997 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The hypoxia-inducible endothelial cell-specific mitogen vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) is expressed in low amounts in adult human brain, but is highly upregulated in the perinecrotic palisading cells of glioblastomas.
|
9370235 |
1997 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Studies of glioblastoma angiogenesis have revealed that expression of the vascular endothelial growth factor (VEGF) is up-regulated in these tumors.
|
9592205 |
1998 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Following incubation of glioblastoma cell lines under hypoxic/anoxic conditions for 24-48 hours, Fas mRNA levels remained unchanged, whereas VEGF expression was markedly upregulated.
|
9600216 |
1998 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The VEGF receptors, kinase domain region (KDR) and Fms-like-tyrosine kinase (Flt-1), also were upregulated in the tumor vasculature of glioblastoma multiforme, anaplastic oligodendrogliomas, and ependymomas with necrosis, whereas the astrocytomas grade II, anaplastic astrocytomas, and oligodendroglioma tumors tended to express a weak to nondetectable signal.
|
9669344 |
1998 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In contrast, VEGF mRNA was expressed in all hemangioblastomas and all glioblastomas.
|
9787178 |
1998 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Glioblastomas are highly vascular tumors which overexpress the angiogenesis factor vascular endothelial growth factor (VEGF).
|
9811337 |
1998 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, in situ hybridization on glioblastoma sections shows that the in vivo expression patterns of IL-8 and VEGF genes overlap, but are not identical.
|
10050881 |
1999 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Due to its properties, VEGF is a candidate for both angiogenesis and vascular permeability/oedema induction which typically occur in glioblastomas.
|
10215998 |
1999 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we report that when protein kinase C (PKC) pathways were activated in human glioblastoma U373 cells by phorbol 12-myristate 13-acetate (PMA), VEGF mRNA expression was up-regulated via a post-transcriptional mRNA stabilization mechanism.
|
10336429 |
1999 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The family of vascular endothelial growth factor (VEGF) proteins include potent and specific mitogens for vascular endothelial cells that function in the lation of angiogenesis Inhibition of VEGF-induced angiogenesis either by neutralizing antibodies or dominant-negative soluble receptor, blocks the growth of primary and metastatic experimental tumors Here we report that VEGF expression is induced in Lewis lung carcinomas (LLCs) both in vitro and vivo after exposure to ionizing radiation (IR) and in human tumor cell lines (Seg-1 esophageal adenocarcinoma, SQ20B squamous cell carcinoma, T98 and U87 glioblastomas, and U1 melanoma) in vitro.
|
10416597 |
1999 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since malignant gliomas frequently show EGF receptor amplification and express IL-1, a pivotal regulatory cytokine involved in angiogenesis, we analyzed interactions between EGF/EGF receptor and IL-1/IL-1 receptor and VEGF in the established glioblastoma cell lines U-87 MG and A-172.
|
10571418 |
1999 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
VEGF expression was found in 21 of 57 astrocytomas WHO grade II (36.8%), in 18 of 27 astrocytomas WHO grade III (66.7%) and in 50 of 78 glioblastomas (64.1%).
|
10778727 |
1999 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the regulatory mechanism of the expression of VEGF by ionizing radiation was studied in three human glioblastoma cells.
|
10885623 |
2000 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined VEGF regulation in U87 MG human glioblastoma cells and in U87/T691 cells, a clonal derivative that contains a truncated erbB2/Neu receptor that interferes with EGFR signaling through the formation of nonfunctional heterodimeric receptor complexes.
|
11059786 |
2000 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expressions of VEGF mRNA in cultured glioblastomas cells were upregulated by hypoxia, but the sensitivity of the cells to hypoxia was reduced as compared with normal rat astrocytes.
|
11303624 |
2000 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Coexpression of VEGF and 150-kDa oxygen-regulated protein (ORP), a novel ER chaperone, in human glioblastoma suggested a link between angiogenesis and ORP150.
|
11358846 |
2001 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we show that substitution of the neutral culture medium (pH 7.3) with acidic pH medium (pH 6.6) up-regulates VEGF mRNA and protein production in human glioblastoma cells as reflected by Northern blot analysis and enzyme-linked immunosorbent assay.
|
11741977 |
2002 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF.
|
11741977 |
2002 |