|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This also occurred in VEGF(189) tumors, but there, vasodilation was less pronounced.
|
14500375 |
2003 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Serum VEGF levels and tumor MVD were significantly higher in Q472H versus KDR wild-type (WD) patients.
|
26631613 |
2016 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Moreover, LINC00628 exerted its tumor suppressive function by repressing the vascular endothelial growth factor A (VEGFA) promoter activity.
|
30740671 |
2019 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
No metastases were detected in mice carrying either wtVEGF or mutant VEGF expressing tumors.
|
11169955 |
2001 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The strong positivity for both PlGF and VEGF observed in our case implies that the t(10;14)(p13;q24) most likely involves PlGF, which may be one of the genes driving oncogenesis in these tumors.
|
16843105 |
2006 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
With some surprise, both VEGF inhibitors (for all patients) and EGFR (for patients with KRAS exon 2 mutant tumors) have failed to improve adjuvant chemotherapy.
|
24727985 |
2014 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Regression analysis indicated that AS transcript of NUMB PRR(L) correlated with tumor size (P<0.01), while AS transcripts of APP and VEGFA correlated with results of laboratory examinations.
|
26261495 |
2015 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PD-L1 levels correlated with the tumor grade (p = 0.013), VEGF status (p = 0.002) and KI-67 status (p = 0.002).
|
28591697 |
2017 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Therefore, we investigated the association of polymorphisms in the VEGF gene with breast cancer risk and prognostic characteristics of the tumors in a large case-control study.
|
15897560 |
2005 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These cells grew slowly and were expanded over a period of 3 years and have maintained characteristics consistent with those of both the original ASPS tumor from the patient and the xenograft tumor including (1) presence of the alveolar soft part locus-transcription factor E3 type 1 fusion transcript and nuclear expression of the alveolar soft part locus-transcription factor E3 type 1 fusion protein; (2) maintenance of the t(X;17)(p11;q25) translocation characteristic of ASPS; and (3) expression of upregulated ASPS transcripts involved in angiogenesis (ANGPTL2, HIF-1-α, MDK, c-MET, VEGF, and TIMP-2), cell proliferation (PRL, PCSK1), metastasis (ADAM9), as well as the transcription factor BHLHB3 and the muscle-specific transcripts TRIM63 and ITGβ1BP3.
|
21552147 |
2011 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
VEGF +936C>T polymorphisms were not directly correlated with poor survival, but they might be associated with increased tumor size, which affected our disease-free survival results.
|
22321253 |
2012 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
It is concluded that inherited VEGF sequence variations, which characterize the tumor genome itself, are strong determinants of the molecular VEGF and VEGF-downstream phenotype of NSCLC.
|
15541813 |
2004 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
AO (serous carcinoma), low malignant potential (LMP; SV40-transformed borderline tumor) and ML-5 (SV40-transformed cystadenoma) cells were examined for VEGF protein production under the regulation of gonadotropins in vitro.
|
11774259 |
2002 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
F134L tumor supernatants showed lower levels of VEGF and endostatin compared with supernatants from tumors expressing other mutants.
|
16723121 |
2006 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
After Bonferroni correction for multiple testing, only one statistical signifcant association between VEGF genotypes and haplotypes and tumor characteristics was observed (-634C allele and small tumor size; p < 0.001).
|
17636397 |
2008 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The tumor-related gene VEGF mRNA fragment was detectable in the urine of cancer patients.
|
25379634 |
2015 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Unexpectedly, VEGF inhibitors and metformin synergize to suppress the growth of BRAF-mutant tumors, revealing a combination of drugs that may be effective in these patients.
|
22576211 |
2012 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In this study, we identified common germline variants in VEGF-dependent and -independent angiogenesis genes predicting clinical outcome and tumor response in patients with mCRC receiving first-line bevacizumab and oxaliplatin-based chemotherapy.
|
21791631 |
2011 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Ultimately, systemic administration of the nanoparticles carrying vascular endothelium growth factor (VEGF) siRNA led to the significant reduction in the subcutaneous BxPC3 tumor growth, well consistent with the enhanced accumulation of siRNA and the significant VEGF gene silencing (~68%) in the tumor.
|
22580114 |
2012 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There was a trend towards an association between positive expression of VEGF and distant metastasis, although these associations were not statistically significant (p = 0.070). p53 mutations were identified in 18 out of 30 (60.0%) tumors.
|
12298426 |
2002 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In contrast, reduction of mutant (V599E)B-Raf activity in preexisting tumors prevented further vascular development mediated through decreased vascular endothelial growth factor secretion, subsequently increasing apoptosis in tumors.
|
15781657 |
2005 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Previous observations suggested that polymorphisms of VEGF and its receptor (VEGFR) genes may regulate angiogenesis and lymphangiogenesis and thus tumour growth control.
|
24510746 |
2014 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We observed that VEGFA locus amplification and/or polysomy represented a small but regularly detected population in several tumour entities while was not present in normal tissues.
|
24114200 |
2014 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Data from 7,525 unique tumor samples (representing 30 tumor cohorts) were retrieved from the TCGA database to analyze the relationship between <i>TP53-</i>mutation status and <i>VEGFA (vascular endothelial growth factor A)</i> expression.
|
31564192 |
2020 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The mean (+/- standard error) VEGF conservation rate for the 33 tumors with mutant K-ras was 1.839 +/- 1.241, and that for the 15 tumors with wild type K-ras was 1.057 +/- 0.983 (P = 0.037).
|
11505392 |
2001 |