|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Higher levels of VEGF mRNA were observed in 12 of 20 HCC and 2 of 9 metastatic liver tumors than in corresponding nontumorous tissues.
|
8617424 |
1996 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells.
|
9242380 |
1997 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
VEGF may play an important role in the invasion and metastasis of HCC.
|
9646228 |
1998 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VEGF expression was also examined in six HCC cell lines.
|
9657098 |
1998 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Vascular endothelial growth factor expression in hypervascular hepatocellular carcinomas was greater than in those not showing hypervascularity.
|
9744316 |
1998 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used a self-contained, tetracycline-regulated retroviral vector system to elucidate the effect of VEGF on murine HCC development in a xenograft experimental model.
|
9828211 |
1998 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There was no significant difference in mean VEGF expression between HCC tumor (1.06+/- 0.43) and adjacent tissue (0.
|
9917513 |
1999 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this article, we demonstrated that VEGF is participated in the tumor angiogenesis of hepatocellular carcinoma, esophageal cancer, and pancreatic cancer.
|
10457902 |
1999 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tumorous and contiguous nontumorous tissues from 25 patients with HCC who underwent curative partial hepatectomy were subjected to Northern blot analysis to detect HME and VEGF messenger RNA (mRNA) expression.
|
10636104 |
2000 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both PD-ECGF and VEGF correlated well with the formation of PVTT of HCC.
|
10641751 |
2000 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Circulating VEGF was derived from HCC tissue. sVEGF concentrations could be a new marker for predicting the angiogenesis, invasion and metastasis of HCC.
|
10746978 |
1999 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that this ribozyme selectively inhibits VEGF gene expression in human hepatocellular carcinoma cells.
|
10938389 |
2000 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of VEGF was observed in all human HCC cell lines examined.
|
11115828 |
2001 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that the hypoxia-inducible enhancer of the human vascular endothelial growth factor gene, which is directly linked to human AFP promoter, involves selective and enhanced tumoricidal activity in gene therapy for hepatocellular carcinoma.
|
11306481 |
2001 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Angiogenesis as assessed by MVD and tumor VEGF expression seems to have a more important role in tumor growth and intrahepatic metastasis in smaller HCCs.
|
11764072 |
2001 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of antisense VEGF RNA in SMMC-7721 cells could decrease the tumorigenicity, and antisense-VEGF gene therapy may be an adjuvant treatment for hepatoma.
|
11819727 |
2001 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fusion of the EGFP significantly triggers tumorigenic VEGF signalling in three E3-, F11- and A(3-1)-transfected human HCC cell lines, compared with the parental EGFP-free malignant hepatocellular carcinoma (MHCC)1 cell line; Redox-regulated VEGF upstream mechanism interplays dramatically mediate dual responses, either down- or upregulating tumorigenic VEGF signalling, which depends on individual post-transcriptional regulation or upstream modification of the VEGF promoter in the three MHCC1, SMCC7721 and doxorubicin-resistance 7402/D+ non-transfected human HCC cell lines; and mechanism-based strategies for stimulating beta-adrenergic and P2-purinergic signal transduction and counteracting O2 and Ca2+-inflow significantly trigger tumorigenic VEGF signalling in ATRA/ATRP-driven networks, compared with controls of the non-transfected cell types examined.
|
11905510 |
2002 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The VEGF receptors might play the major role in HCC angiogenesis and prognosis.
|
12017318 |
2002 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggested that intracellular suppression of VEGF-A gene was specifically linked to up-regulation of MMP1 in human hepatocellular carcinoma cells.
|
12063553 |
2002 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
[Correlation between epidermal growth factor and overexpression of vascular endothelial growth factor in hepatocellular carcinoma].
|
12667326 |
2002 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies have found that the ACE inhibitor, perindopril (PE), which is a potent inhibitor of experimental HCC growth and angiogenesis, is associated with the suppression of VEGF at a clinically comparable dose.
|
12677092 |
2003 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Distortion of autocrine transforming growth factor beta signal accelerates malignant potential by enhancing cell growth as well as PAI-1 and VEGF production in human hepatocellular carcinoma cells.
|
12700666 |
2003 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, distortion of autocrine TGF-beta signals in human HCC accelerates their malignant potential by enhancing cell growth as well as PAI-1 and VEGF production.
|
12700666 |
2003 |
|
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VEGF messenger RNA (mRNA) was significantly up-regulated in HCC compared to normal liver tissue from patients with hepatic metastases.
|
12717391 |
2003 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF) and angiopoietins (Ang1 and Ang2) are endothelial cell-specific vasculogenic and angiogenic growth factors, but their expression and roles in HCC have not been extensively explored.
|
12808060 |
2003 |