|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Papillary and follicular carcinomas express intermediate levels of VEGF mRNA.
|
7478581 |
1995 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In all of the paired cases, VEGF expression was markedly increased in the carcinomas.
|
8616842 |
1996 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that VEGF may confer angiogenesis and progression of human gastric carcinomas, especially of the well-differentiated type.
|
9701011 |
1998 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have assumed that VEGF contributes to aggressive characteristics in oesophageal carcinomas and that VEGF expression might be affected by p53 status.
|
9635853 |
1998 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Low VEGF protein expression was seen in four of the five chromophilic renal carcinomas.
|
10475065 |
1999 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Carcinomas with the greatest contents of VEGF mRNA and VEGF protein had the most intense mitogenic activity.
|
10194527 |
1999 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, 27 carcinomas (67.5%) were evaluated to be VEGF-positive, whereas 13 carcinomas (32.5%) were VEGF-negative.
|
10188906 |
1999 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Compared with the untreated controls, significantly lower levels of vascular endothelial growth factor expression were observed in a sizeable proportion of the Se-treated carcinomas.
|
10569799 |
1999 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Forty-six carcinomas (25.4%) were evaluated as having high VEGF expression, and 135 tumors (74.6%) had low VEGF expression.
|
10675482 |
2000 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Neither VEGF mRNA nor VEGF protein was detected in any of the mild-to-moderate dysplastic adenomas, whereas 16 of 26 m carcinomas (62%) and all sm carcinomas exhibited VEGF protein.
|
10760758 |
2000 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
VEGF(121,165) mRNA was decreased in proliferatively active carcinomas compared to less proliferative tumors.
|
11764385 |
2001 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Although the importance of VEGF-A has been shown in renal carcinomas, the contribution of these new ligands in kidney tumors is not clear.
|
11306510 |
2001 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
VEGF expression was same in adenomas and cancers while dThdPase was weak in adenomas but strongly expressed in invasive carcinomas ( > T1).
|
11669335 |
2001 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Trx-1 transfection also caused a significant increase in the protein products of hypoxia-responsive genes, including vascular endothelial growth factor (VEGF) and nitric oxide synthase 2 in a number of different cell lines (MCF-7 human breast and HT29 human colon carcinomas and WEHI7.2 mouse lymphoma cells) under both normoxic and hypoxic conditions.
|
12208766 |
2002 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
There was no relationship between HIF-1 alpha or VEGF gene expression level and IMD in all carcinomas (R=0.118 and 0.224, respectively).
|
11804750 |
2002 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of vascular endothelial growth factor and p53 in pancreatic carcinomas.
|
12298426 |
2002 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The decrease in VEGF-D occurring in polyps and carcinomas may allow the higher levels of VEGF-A and VEGF-C to bind more readily to the VEGF receptors, and produce the angiogenic switch required for tumor growth.
|
11687953 |
2002 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The VEGF receptors fetal liver kinase-1 (Flk-1) and Fms-like tyrosine kinase-1 (Flt-1) become highly expressed in epithelial tumor and endothelial cells in the mammary carcinomas, suggesting a potential autocrine effect for VEGF on tumor cell growth.
|
12209972 |
2002 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We also compared mRNA and protein expression levels using immunohistochemistry for epidermal growth factor receptor (EGFR), matrix metalloproteinase (MMP)-1, p21, and vascular endothelial growth factor (VEGF) in 15 randomly selected and routinely processed oral carcinomas.
|
12218216 |
2002 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutations in the tumor-suppressor gene VHL cause oversecretion of vascular endothelial growth factor by clear-cell renal carcinomas.
|
12890841 |
2003 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, VEGF and TP53 expression did not appear to be involved in metastasis in MSI-H colon carcinomas.
|
12939742 |
2003 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MSI+ mucinous carcinomas had a lower MVD and VEGF expression than other MSI+ carcinomas (P=0.008 and P=0.004, respectively) and MSI- mucinous carcinomas (P=0.01 and P=0.001, respectively).
|
12596060 |
2003 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
By immunhistochemistry, high-grade, high-stage carcinomas less frequently displayed areas with a strong reactivity for the VEGF protein ('hot spots") than low-grade, low-stage TCC, paralleling the expression of the mRNA.
|
15517881 |
2004 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MVDs and VEGF RNA expression measured by quantitative RT-PCR were found to be elevated in comparison to normal bronchial tissue in bronchial dysplasias and invasive lung carcinomas but not in basal cell hyperplasias.
|
15777969 |
2005 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of vascular endothelial growth factor (VEGF) and its cognate receptor KDR has been linked to a more aggressive phenotype of human prostate carcinomas.
|
15616600 |
2005 |