Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we analyzed the effects of hypoxia, a common feature of solid tumors and a major drive to tumor angiogenesis, and of PA, a tryptophan catabolite produced under inflammatory conditions and endowed with several biologic properties, on the production of the angiogenic activator VEGF by advanced-stage human NB cell lines.
|
12115498 |
2002 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The redundancy in angiogenic factor expression suggests that inhibition of VEGF bioactivity alone might not be a sufficient approach for antiangiogenic therapy of human NB.
|
10815914 |
2000 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VEGF and NRP-1 expression was also demonstrated in human NBL specimens.
|
16193833 |
2005 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients with high miR-337-3p expression had greater survival probability. miR-337-3p suppressed the promoter activity, nascent transcription, and expression of MMP-14, resulting in decreased levels of vascular endothelial growth factor, in cultured NB cell lines.
|
26084291 |
2015 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An increase in VEGF levels was also found in lysates of irradiated neuroblastoma cells.
|
17088992 |
2006 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found VEGF mRNA in neuroblastoma cells but not vascular endothelial cells according to in situ hybridization.
|
12483647 |
2002 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since BDNF is reported to stimulate VEGF expression and/or release in neuroblastoma cells, the present study tested the hypothesis that the actions of BDNF are mediated by VEGF.
|
30712809 |
2019 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo, h10H5 shows single-agent antitumor efficacy in human SK-N-AS neuroblastoma and SW527 breast cancer xenograft models and even greater efficacy in combination with the chemotherapeutic agent docetaxel or an anti-vascular endothelial growth factor antibody.
|
18790743 |
2008 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ALK knockdown was associated with marked reductions in vascular endothelial growth factor (VEGF) secretion, blood vessel density, and matrix metalloproteinases (MMPs) expression in vivo, suggesting a role for ALK in NB-induced neoangiogenesis and tumor invasion, confirming this gene as a fundamental oncogene in NB.
|
21829174 |
2011 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, BDNF was identified as a potential proangiogenic factor for the promotion of endothelial cell survival, induction of neoangiogenesis in ischemic tissues, and increase of VEGF expression in neuroblastoma.
|
20331634 |
2010 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results further suggest that a persistent blocker of stroma-derived VEGF will need to be combined with CPT-11 to completely inhibit the growth of chemosensitive NB, and that administration of CPT-11 at higher doses will be required to inhibit the growth of multidrug-resistant NB.
|
18384433 |
2008 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
N-myc is a novel regulator of PI3K-mediated VEGF expression in neuroblastoma.
|
18278068 |
2008 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression or knockdown of miR-9 responsively altered both the mRNA and protein levels of MMP-14 and its downstream gene, vascular endothelial growth factor, in cultured neuroblastoma cell lines SH-SY5Y and SK-N-SH.
|
22564723 |
2012 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that VEGF(165) is up-regulated in NB and that there is a difference in the balance of isoform expression from anti-angiogenic VEGF(165)b to angiogenic VEGF(165).
|
20662003 |
2010 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this regard, a more promising target to inhibit NB angiogenesis seems to be the VEGF/VEGFR system.
|
14605672 |
2003 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study showed that concentrations of HGF and S-VEGF-A are elevated in patients with NB.
|
19661350 |
2009 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IMR-32 human neuroblastoma cells are cultured with VEGF at varying times and in escalating doses.
|
15882878 |
2005 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We will also discuss a variety of vascular inhibition strategies that have been used in neuroblastoma preclinical models including specific inhibition of vascular endothelial growth factor (VEGF) and methionine aminopeptidase 2 (MetAP2).
|
15927358 |
2005 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma.
|
15064733 |
2004 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This conclusion was based on in vitro transfection with pre-miR-93-5p and anti-miR-93-5p; these treatments inversely modulated both VEGF and IL-8 gene expression and protein release in the neuroblastoma SK-N-AS cell line.
|
26986724 |
2016 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gain- and loss-of-function studies indicated that secretory ITLN1 facilitated the NDRG2 expression, resulting in down-regulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinase 9 (MMP-9), in NB cell lines SH-SY5Y, SK-N-BE(2), and SK-N-SH.
|
25889839 |
2015 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have thus demonstrated that NB cell adaptation to hypoxia, in addition to the modulation of HIF1alpha and VEGF expression and nuclear translocation of ID1 and ID2 transcription factors, involve in the activation of a gene expression program consistent with the pro-metastatic events.
|
19423615 |
2009 |
Childhood Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Similarly, MYCN transfection of the neuroblastoma cell line SH-EP induced the upregulation of VEGF-A and -D and the switching-off of sVEGFR-2.
|
20179233 |
2010 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show here that this engineered ZFP-TF activates VEGF-A in appropriate cells in culture and that the secreted VEGF-A protein induced by the ZFP protects neuroblastoma cell lines from a serum starvation insult in vitro.
|
16731852 |
2006 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present findings indicated that the interplay between the p53/caspase pathway and the linc01105/miR‑6769b‑5p/VEGFA axis may have important roles in the development of neuroblastoma.
|
31524279 |
2019 |