Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE PTHrP treatment of colon cancer cells promotes tumor associated-angiogenesis by the effect of VEGF. 30639585 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE Serum vascular endothelial growth factor (VEGF) concentrations in colon cancer patients of the two groups were evaluated before and after chemotherapy. 31127996 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE This study aimed to evaluate the prognostic value of MVD in stage II and III colon cancer and its relation to tumour-stroma-percentage (TSP) and expression of HIF1A and VEGFA. 31420015 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE Stimulation of colon cancer cells with VEGF-A and placental growth factor (PlGF) activated VEGF receptor-1 (VEGFR-1) and increased proliferation activity in an autocrine EGF/EGF receptor (EGF-R)-dependent manner. 31717527 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE Chemokine receptor 7 targets the vascular endothelial growth factor via the AKT/ERK pathway to regulate angiogenesis in colon cancer. 31348616 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE A gene signature comprising LAMA1, ITGB1, ITGA2, CXCR4 and VEGFA has negative predictive value in colon cancer. 29907957 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE The aim was to investigate the predictive value of postoperative VEGF serum concentration in patients undergoing surgery for colon cancer. 28683891 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE We have used 20 Male wistar rats for the formation of colon cancer model and utilized albumin as carrier molecule for the delivery of siRNA against vascular endothelial growth factor receptor 2 (VEGF R2). 29709588 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE We examined the effect of genipin on the intracellular level of HIF-1α and extracellular level of VEGF using the colon cancer cell line HCT116. 29630948 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE miR‑1 inhibits the progression of colon cancer by regulating the expression of vascular endothelial growth factor. 29845255 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE The rationale for this therapeutic approach is based on the fact that antiangiogenic drugs can make tumors hypoxic, and thus more sensitive to PIM inhibitors.<b>Experimental Design:</b> Xenograft and orthotopic models of prostate and colon cancer were used to assess the effect of PIM activation on the efficacy of VEGF-targeting agents. 29084916 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE We evaluated the efficacy of bevacizumab-based anti-angiogenesis in combination with PDT as well as the resulting VEGF levels and microvessel density (MVD) in a mouse model of human colon cancer. 29894822 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE ALA PDT used in sublethal doses decreases release of VEGF in more aggressively growing SW620 colon cancer cell line in hypoxia-like conditions. 29079348 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE We evaluated the influence of 28 single-nucleotide polymorphisms in 12 genes in the VEGF pathway on the prognosis of 347 patients with stage II-III colon cancer. 29282362 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE These factors could allow neoplastic tissues to survive and withstand the stress induced by hypoxia and/or disruption of the ECM, including vascular endothelial growth factor and matrix metalloproteinases that were found to be highly elevated in tumor tissues of colon cancer patients. 28245762 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE Here, we show that colon cancer cells express high levels of VEGF, total HER2 and phosphorylated HER2, and simvastatin apparently decreased their expression in HER2-overexpressing colon cancer cells. 27887848 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE Bevacizumab, an inhibitor of vascular endothelial growth factor (VEGF)-A, is currently used to treat patients with ovarian or colon cancer. 28966326 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE Biopsies were collected from 86 patients with advanced colon cancer and sections were stained by immunohistochemistry for VEGF. 28245709 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer. 28415573 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE Taken together, our study provides evidences showing that miR-299-3p functions as a suppressor in colon cancer by targeting VEGFA, suggesting that miR-299-3p might serve as a novel target for colon cancer therapy. 28738498 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 Biomarker disease BEFREE Smad4 Inhibits VEGF-A and VEGF-C Expressions via Enhancing Smad3 Phosphorylation in Colon Cancer. 28445620 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE Collectively, our results indicate that SARI is a potential target for therapy by inhibiting angiogenesis through the reduction of VEGF expression and is a prognostic indicator for patients with colon cancer. 27353863 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE Biglycan up-regulated vascular endothelial growth factor (VEGF) expression and promoted angiogenesis in colon cancer. 25371074 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. 26209639 2015
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.600 AlteredExpression disease BEFREE This study showed that Lcn2-engineered MSCs (MSC-Lcn2) not only inhibited liver metastasis of colon cancer but also downregulated the expression of vascular endothelial growth factor (VEGF) in the liver. 25740061 2015