Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Long-term follow-up and safety assessment of angiogenic gene therapy trial VIF-CAD: Transcatheter intramyocardial administration of a bicistronic plasmid expressing VEGF-A165/bFGF cDNA for the treatment of refractory coronary artery disease.
|
31288177 |
2019 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Relative levels of miRNA-26a-5p, the gene of phosphate and tension homology deleted on chromosome ten (PTEN) and vascular endothelial growth factor (VEGF) in CAD patients and coronary endothelial cells isolated from CAD mice were examined.
|
31210329 |
2019 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We aimed at investigating the functions of endothelial progenitor cells (EPCs) in the pathophysiology of coronary artery spasm (CAS) and coronary artery disease (CAD), as well as to evaluate the correlation of these diseases with the number and function of EPCs, the plasma concentration of vascular endothelial growth factor 165 (VEGF165) and stromal cell-derived factor 1 (SDF-1).
|
29771429 |
2018 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) that compared VEGF gene therapy and standard treatments in CAD.
|
30035366 |
2018 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Vascular endothelial growth factor gene polymorphisms and coronary heart disease: a systematic review and meta-analysis.
|
30317903 |
2018 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, we concluded that the VEGF gene polymorphisms rs699947, rs2010963, and rs3025039 are correlated with an elevated CAD risk.
|
29973139 |
2018 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It can be thus suggested that rs2010963 VEGF gene can be considered as a genetic risk predictor for CAD and its outcomes.
|
27704620 |
2017 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Vascular endothelial growth factor A polymorphisms are associated with increased risk of coronary heart disease: a meta-analysis.
|
28430629 |
2017 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of miR-20 was significantly lower in CAD group where the VEGF and PTEN were upregulated, compared to non-CAD group.
|
28888922 |
2017 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In univariate analysis, all three VEGF polymorphisms (460C, 1154A, and 2578A) were significantly associated with a higher prevalence of coronary artery disease (P < .01) and greater frequencies of hypertension were found in carriers of the 1154A allele and the 2578A allele (P = .01).
|
28364978 |
2017 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the cooperative paracrine signaling profile in response to Vascular Endothelial Growth Factor (VEGF) gene therapy in patients with coronary artery disease (CAD) and refractory angina.
|
27997860 |
2017 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of Genetic Polymorphisms on Vascular Endothelial Growth Factor and its Receptor Genes with Susceptibility to Coronary Heart Disease.
|
26726843 |
2016 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
CONCLUSIONS As suggested by our study, MiR-206 can be a novel benign biomarker for CAD because it may regulate VEGF expression.
|
27994218 |
2016 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to analyze the relationships between functional polymorphisms in genes encoding basic fibroblast growth factor (bFGF, FGF2), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), platelet derived growth factor-B (PDGFB), transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor A (VEGF-A) and the severity of coronary atherosclerosis in patients with stable CAD undergoing their first coronary angiography.
|
27835972 |
2016 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Age and CAD were associated with reduced CAC intrinsic migration (but not specific response to vascular endothelial growth factor, adherence of CACs to endothelial tubes, eNOS mRNA and protein levels, and NO production.
|
26738788 |
2016 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Little is known about the concomitant presence of the angiotensin-converting enzyme (ACE) (rs4646994) D allele and vascular endothelial growth factor(VEGF) (+405G/C; rs2010963) G allele on the susceptibility of coronary artery disease (CAD).
|
24505095 |
2015 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between VEGF polymorphisms (936c/t, -460t/c and -634g/c) with haplotypes and coronary heart disease susceptibility.
|
25755796 |
2015 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We aimed to investigate the correlation between the levels of circulating miR-214 and the expression of vascular endothelial growth factor (VEGF) in the pathogenesis of coronary heart disease patients to further explore the mechanism involved in the vasculogenesis.
|
25575606 |
2015 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, VEGF serum levels were analyzed in 98 subjects with type 2 diabetes without CAD.
|
25128838 |
2014 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, how miRNAs and VEGF cooperate to regulate CAD progression is still unclear.
|
24865854 |
2014 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The vascular endothelial growth factor (VEGF) signaling pathway was the only selected significant pathway related with CAD in the interaction network (p < 0.05).
|
24247647 |
2014 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
KLK1, VEGF and hs-CRP plasma levels were measured in 100 patients newly diagnosed with CAD and 33 CAD-free controls.
|
23639635 |
2013 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To identify the markers contributing to the genetic susceptibility to CAD, we examined the potential association between CAD and 10 single nucleotide polymorphisms (SNPs, rs699947, rs1570360, rs2010963, rs833068, rs3024997, rs3025000, rs3025010, rs3025020, rs3025030, rs3025039) of the VEGF gene using the MassARRAY system.
|
23545315 |
2013 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The objective of the current study was to ascertain the safety profile of good manufacturing practice (GMP)-grade AdVEGF-All6A+ in the adult rat ischemic heart model in support of a clinical study to treat humans with diffuse CAD.
|
23692382 |
2013 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analyses revealed that the VEGFA rs699947 C/A, VEGFA rs2010963 G/C, and VEGFA rs3025039 C/T polymorphisms were not associated with a risk of CAD.
|
23880405 |
2013 |