|
Malignant neoplasm of kidney
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
VHL mutations in renal cell cancer: does occupational exposure to trichloroethylene make a difference?
|
15177666 |
2004 |
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The von Hippel-Lindau tumor suppressor gene and kidney cancer.
|
15448019 |
2004 |
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
In conclusion, unlike other hereditary kidney cancer-related genes (i.e., VHL and MET), which are cell type-specific, BHD is involved in the entire spectrum of histological types of renal tumors, suggesting its major role in kidney cancer tumorigenesis.
|
12907635 |
2003 |
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition to VHL, which is associated with clear cell carcinoma, one can now list HPRC (associated with type I papillary renal cancer) and HLRCC (associated with type II papillary renal cancer).
|
14521208 |
2003 |
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
This review summarizes the current knowledge of the molecular pathogenesis of von Hippel-Lindau disease and the role of the VHL gene product (pVHL) in kidney cancer and the mammalian oxygen sensing pathway.
|
14569079 |
2003 |
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recent identification of VHL, c-met and TSC as candidate genes mutated in various types of renal carcinomas has greatly enhanced our understanding of the pathogenesis of renal carcinomas and has provided novel therapeutic options for patients with renal cancer.
|
11753085 |
2002 |
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.
|
12032852 |
2002 |
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
CTD_human |
Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors.
|
11880179 |
2002 |
|
Malignant neoplasm of kidney
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
pVHL, the product of the VHL tumor suppressor gene, plays an important role in the regulation of cell growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer.
|
10421634 |
1999 |
|
Malignant neoplasm of kidney
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we collected 35 archived Swedish sporadic RCCs identified from an epidemiological study on occupational exposure and kidney cancer to test how well stored pathological specimens could be retrieved and analyzed for VHL mutations.
|
10454237 |
1999 |
|
Malignant neoplasm of kidney
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
The VHL tumour-suppressor gene (TSG) has a critical 'gatekeeper' role in regulating growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer.
|
9820032 |
1998 |
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The VHL gene is a powerful tool for the study of the biology and diagnosis of kidney cancer.
|
7754256 |
1995 |
|
Malignant neoplasm of kidney
|
0.700 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Malignant neoplasm of kidney
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|