Kidney Neoplasm
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
In this study, we aimed to investigate the relation between the mRNA expression levels of VHL, TIMP-3 and RASSF1A genes, and the histopathological and clinical characteristics of patients with renal tumors.
|
31773698 |
2019 |
Kidney Neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We also confirmed the presence of specific VHL mutations in ctDNA derived from RCC xenografts indicating the capability of renal tumors to release DNA into the blood circulation.
|
28214514 |
2017 |
Kidney Neoplasm
|
0.900 |
PosttranslationalModification
|
disease |
BEFREE |
VHL inactivation is the most established molecular characteristic of clear cell renal cell carcinoma (ccRCC), with only a few additional genes implicated in development of this kidney tumor.
|
26169495 |
2015 |
Kidney Neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The majority of renal tumors in adults are clear cell renal cell carcinomas, which are characterized by von Hippel- Lindau (VHL) gene alterations.
|
25619751 |
2015 |
Kidney Neoplasm
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Clear cell renal cell carcinomas (ccRCCs) are characterized by biallelic loss of the von Hippel-Lindau tumor suppressor and subsequent constitutive activation of the hypoxia-inducible factors, whose transcriptional programs dictate major phenotypic attributes of kidney tumors.
|
24356968 |
2014 |
Kidney Neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Re-evaluation of histological type by immunohistochemical and genetic study of transcription factors (TFE3 and TFEB) of VHL gene mutation-negative clear cell renal cell carcinoma and other special types of renal tumor.
|
21424937 |
2011 |
Kidney Neoplasm
|
0.900 |
AlteredExpression
|
disease |
LHGDN |
[Inactivation of the VHL gene in sporadic clear cell renal cancer].
|
18389622 |
2008 |
Kidney Neoplasm
|
0.900 |
GeneticVariation
|
disease |
LHGDN |
Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.
|
17526729 |
2007 |
Kidney Neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
The mechanism of renal tumor suppression by VHL protein is only partly elucidated.
|
14973063 |
2004 |
Kidney Neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
The anti-pVHL(30)/pVHL(19) antibody showed nuclear and cytoplasmic pVHL expression, whereas the anti-pVHL(30) antibody (Ig33) detected cytoplasmic pVHL expression, suggesting that the distribution of VHL protein isoforms varies in the nuclear and cytoplasmic compartments of renal tumors.
|
12937142 |
2003 |
Kidney Neoplasm
|
0.900 |
AlteredExpression
|
disease |
LHGDN |
Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells.
|
12767066 |
2003 |
Kidney Neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
His right-kidney tumour carried a different VHL mutation and loss of heterozygosity (LOH) was not detected.
|
12522559 |
2003 |
Kidney Neoplasm
|
0.900 |
Biomarker
|
disease |
RGD |
Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors.
|
11880179 |
2002 |
Kidney Neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
Mutations of the von Hippel-Lindau tumor suppressor protein are found in most clear cell renal cell carcinomas (CC-RCCs) but not other renal tumors, raising a question about the importance of activation of the HIF pathway in CC-RCC development.
|
12019178 |
2002 |
Kidney Neoplasm
|
0.900 |
Biomarker
|
disease |
CTD_human |
Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors.
|
11880179 |
2002 |
Kidney Neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we identified a de novo germline mutation in the VHL gene of a young patient and a somatic chromosome 3p loss at the homologous chromosome 3 in his renal tumor.
|
8641695 |
1996 |
Kidney Neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
64 kidney tumours of clear cell histopathology were analysed with non-isotopic SSCP and HA for the presence of VHL gene defects.
|
8739330 |
1996 |
Kidney Neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We studied VHL gene mutation in 31 kidney tumors from France.
|
7591282 |
1995 |
Kidney Neoplasm
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Kidney Neoplasm
|
0.900 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Kidney Neoplasm
|
0.900 |
CausalMutation
|
disease |
CGI |
|
|
|