VIP, vasoactive intestinal peptide, 7432

N. diseases: 376; N. variants: 2
Disease: Down Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.310 Biomarker disease CTD_human In infants with Down syndrome, concentrations of IL-8 levels were higher than in controls, whether or not corrected for total protein; NT-3 and CGRP were lower and VIP higher. 16289943 2006
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.310 Biomarker disease BEFREE This study indicates that VIP anomalies are present in neonatal Ts65Dn mice, a defect occurs in the signal transduction mechanism of the VPAC-1 VIP receptor, cortical astrocytes from neonatal brains are dysfunctional, and further, that VIP dysregulation may play a significant role in DS. 17401158 2006