Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE In CP-W, pinprick hyperalgesia and increased sensitivity to capsaicin were aligned with increased epidermal TRPV1 expression, while smaller histamine axon reflex erythema matched with significantly reduced intraepidermal nerve fiber density. 30938826 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE Intrathecal administration of the TRPV1 siRNA not only attenuated behavioural hyperalgesia but also reduced the expression of TRPV1 and CAMKII, as well as ERK2 phosphorylation. 30808963 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion. 30822229 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE Our data suggest that H<sub>2</sub>S leads to hyperalgesia in diabetic rats through activation of TRPV1, TRPA1 and TRPC channels and, subsequent intraepidermal fibers loss. 30602386 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Our findings suggested that TRPV1 is involved in the TRPV1-PKC signaling pathway, which contributes to the persistence of remifentanil-induced postoperative hyperalgesia. 31568203 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE The aim of this study is the contribution of TRPV1 to the surface expression of <i>N</i>-methyl-d-aspartate (NMDA) receptors in remifentanil-induced postoperative hyperalgesia. 30863139 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Selective pharmacological blockade of TRPA1 or TRPV1 showed that TRPA1 is crucially involved in MG-induced chemical pain sensation and heat hyperalgesia. 31219946 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE By precisely removing a unique PKC phosphorylation site (TRPV1 S801) in mice through CRISPR/Cas9 editing, we provide <i>in vivo</i> evidence for a highly specific inhibition that leaves basal TRPV1 function intact, yet alleviates some forms of hyperalgesia. 31676602 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE In vivo, local administration of TRPV1 antagonists into the lateral habenula attenuated hyperalgesia, anxiety, and relapse-like drinking in rats who chronically consumed alcohol.The data suggest that enhanced TRPV1 channel function during withdrawal may contribute to aberrant behavior that promotes relapse alcohol consumption. 30676422 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE TRPV1 contributes to peripheral sensitization and hyperalgesia, in part, <i>via</i> triggering the release of proinflammatory peptides, such as calcitonin gene-related peptide (CGRP), both locally and at the dorsal horn of the spinal cord. 31551772 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Similarly, NTG injection produced significant hindpaw mechanical allodynia or facial cold allodynia, but not heat hyperalgesia in transient receptor potential type V1 (TRPV1) knockout mice. 29187670 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 PosttranslationalModification phenotype BEFREE Oral administration of curcumin attenuates visceral hyperalgesia through inhibiting phosphorylation of TRPV1 in rat model of ulcerative colitis. 28812431 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE SZV 1287 significantly inhibited both TRPA1 and TRPV1 activation-induced acute chemonociception and hyperalgesia. 29438782 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE CFA-induced inflammatory hyperalgesia did not alter TRPV1 expression in the trigeminal ganglia from male rats. 29209900 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE We studied the possible role of TRPV1 and TRPV4 in transducing cancer-induced hyperalgesia. 29637027 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management. 29237283 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia. 30015706 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE The KChIP3-TRPV1 interaction reduces the surface localization of TRPV1 and thus alleviates heat hyperalgesia and gait alterations induced by peripheral inflammation. 29335353 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE Our data suggest that luminal PAR2 stimulation in the bladder causes prostanoid-dependent referred hyperalgesia in mice, which involves the activation of TRPV1 and T-type Ca<sup>2+</sup> channels. 29289470 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE The prevention of this hyperalgesia by diclofenac (1-10μg), the inhibitors of COX-1 SC-560 (0.1-1μg) or COX-2 celecoxib (1-5μg), the TRPV1 antagonist capsazepine (0.03-0.3μg) or the TRPA1 antagonist HC030031 (10-50μg) demonstrates the involvement of prostaglandin synthesis and TRP sensitization in CCL5-evoked hyperalgesia. 28126501 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE Activation of TRPV1 receptors and NGF-signaling pathways may contribute to heat hyperalgesia induced by ET-1. 28865353 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Phα1β did not affect calcium responses evoked by selective TRPV1 (capsaicin) or TRPV4 (GSK 1016790A) agonists on the various cell types.Intrathecal (i.t.) and intraplantar (i.pl.) administration of low doses of Phα1β (up to 300 pmol per paw) attenuated acute nociception and mechanical and cold hyperalgesia evoked by AITC (i.t. or i.pl.), without affecting responses produced by capsaicin or hypotonic solution. 27759880 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 Biomarker phenotype BEFREE Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium. 29235496 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 GeneticVariation phenotype BEFREE p38 signaling cascades are involved in tongue heat hyperalgesia in association with TRPV1 upregulation in TG neurons innervating the TNBS-treated tongue. 28973050 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.600 AlteredExpression phenotype BEFREE We conclude that one of the possible regulatory mechanisms of TNF in pain involves upregulation of the nociceptor TRPV1, and that peripheral treatment with a selective anti-soluble TNF biologic can prevent hyperalgesia caused by inflammation in the orofacial region. 29132095 2017