|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Natural product-drug conjugates for modulation of TRPV1-expressing tumors.
|
30885569 |
2019 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A significant percentage of tumors exhibited TRPV1-4 channel expression which was independent of the proliferation index of the tumors but was significantly associated with histopathological subtypes.
|
31119368 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We find that TRPV1 knockout promotes to hepatocarcinogenesis and deconstructs the portal triad adjacent to tumor border that is contributed by originations of tumor initiating cells and biliary cells.
|
31401394 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we hypothesized that TRPV1 is a tumor suppressor in CRC development as well as the underlying mechanism.
|
31183372 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Altogether, our study demonstrates that TRPV1 is a potential tumor suppressor in melanoma.
|
29580868 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In vitro and in vivo studies suggested that the potent TRPV1 competitive antagonist AMG-9810 promoted proliferation in N/TERT1 cells (telomerase-immortalised primary human keratinocytes 1) and tumour development in mouse skin that was mediated through EGFR/Akt/mTOR signalling.
|
28815372 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
TRPV1 expression was decreased in RCC, which was significantly associated with tumor Fuhrman grades and histopathological subtypes.
|
29970964 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Transient receptor potential vanilloid 1 (TRPV1) polymodal channel is expressed in different neoplastic tissues and cell lines of breast cancer and associated with the regulation of tumor growth, tumor neurogenesis, cancer pain, and malignant progression of cancer.
|
30410392 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Repeated morphine treatment for a period of 8 days induced upregulation of the TRPV1 protein expression levels in the DRG in the tumor‑bearing rats, although no change in mRNA expression.
|
28901432 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This review focuses on how up-regulated glutamate production and export by the tumour converge at peripheral afferent nerve terminals to transmit nociceptive signals through the transient receptor cation channel, TRPV1, thereby initiating central sensitization in response to peripheral disease-mediated stimuli.
|
27157265 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Altogether, our results suggest that PTHrP and mild acidic conditions could induce constitutive pathological activation of sensory neurons through upregulation of TRPV1 function and trafficking, which could serve as a mechanism for peripheral sensitization of nociceptive afferents in the tumor microenvironment.
|
25970319 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
NPC-mediated tumor suppression can be mimicked in the adult brain by systemic administration of the synthetic vanilloid arvanil, suggesting that TRPV1 agonists have potential as new HGA therapeutics.
|
22820645 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
However, we previously reported that the absence of TRPV1 in mice results in a striking increase in skin carcinogenesis, suggesting that chronic blockade of TRPV1 might increase the risk of tumor development.
|
21349818 |
2011 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1).
|
21310942 |
2011 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
TRPV1 plays a crucial role in the transmission of pain signals, especially under inflammation and the neoplasm conditions, and it can also modulate nociceptive afferents by reinforcing morphine tolerance.
|
19633705 |
2009 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, while the increased expression of TRPV1 showed a proper correlation with increasing PCC tumor grades, such phenomenon was not observed with CB1.
|
18830626 |
2009 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To elucidate its role in hepatocarcinogenesis, we analyzed the expression of VR1 receptor in tumor and nontumor tissues from human hepatocellular carcinoma (HCC) samples.
|
18786439 |
2008 |